Extracts of Selected South African Medicinal Plants Mitigate Virulence Factors in Multidrug-Resistant Strains of .

The emergence of multidrug-resistant (MDR) remains a global health threat due to its alarming rates of becoming resistant to antibiotics. Therefore, identifying plant-based treatment options to target this pathogen's virulence factors is a priority. This study examined the antivirulence activities of twelve plant extracts obtained from three South African medicinal plants (, and ) against carbapenem-resistant (CBR) and extended-spectrum beta-lactamase (ESBL) positive strains.

Correction: Adeosun et al. Anti-Biofilm and Associated Anti-Virulence Activities of Selected Phytochemical Compounds against . 2022, , 1429.

In the original publication [...

Molecular modelling of SdiA protein by selected flavonoid and terpenes compounds to attenuate virulence in .

is one of the perturbing multidrug resistant (MDR) and ESKAPE pathogens contributing to the mounting morbidity, mortality and extended rate of hospitalization. Its virulence, often regulated by quorum sensing (QS) reinforces the need to explore alternative and prospective antivirulence agents, relatively from plants secondary metabolites. Computer aided drug discovery using molecular modelling techniques offers advantage to investigate prospective drugs to combat MDR pathogens.

Anti-Biofilm and Associated Anti-Virulence Activities of Selected Phytochemical Compounds against .

The ability of to form biofilm renders the pathogen recalcitrant to various antibiotics. The difficulty in managing related chronic infections is due to its biofilm-forming ability and associated virulence factors, necessitating the development of efficient strategies to control virulence factors. This study aimed at evaluating the inhibitory potential of selected phytochemical compounds on biofilm-associated virulence factors in , as well as authenticating their antibiofilm activity.

Quorum sensing modulation and inhibition in biofilm forming foot ulcer pathogens by selected medicinal plants.

The crisis of antibiotic resistance necessitates the search of phytochemicals as potential antibacterial, anti-quorum sensing and antibiofilm forming agents. For the present study, fifteen (15) selected medicinal plants were evaluated to inhibit the biological activities of multi-drug resistant (MDR) pathogenic bacteria (, , , and ) associated with diabetic foot ulcer. Antibacterial activities revealed noteworthy minimum inhibitory concentration (MIC) values ≤1 mg/mL for thirteen (13) out of the sixty (60) plant extracts screened.

In Silico and In Vitro Screening of Antipathogenic Properties of (Vahl) against .

Bacterial quorum sensing (QS) system regulates pathogenesis, virulence, and biofilm formation, and together they contribute to nosocomial infections. Opportunistic pathogens, such as , rely on QS for regulating virulence factors. Therefore, blocking the QS system may aid management of various infectious diseases caused by human pathogens.