Publications by authors named "Itsuki Sakai"
The functional significance of the morphological and genetic changes that occurred in the brain during evolution is not fully understood. Here we show the relationships between evolutionary changes of the brain and glymphatic circulation. We establish a mathematical model to simulate glymphatic circulation in the cerebral hemispheres, and our results show that cortical neurons accumulate in areas of the cerebral hemispheres where glymphatic circulation is highly efficient.
View Article and Find Full Text PDFOrganoids, which can reproduce the complex tissue structures found in embryos, are revolutionizing basic research and regenerative medicine. In order to use organoids for research and medicine, it is necessary to assess the composition and arrangement of cell types within the organoid, i.e.
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- Short half-lives and poor blood-brain barrier transport limit the effectiveness of cytokines and growth factors as receptor agonists.
- A new method called 'lasso-grafting' was used to genetically engineer macrocyclic peptide pharmacophores into the Fc region of human immunoglobulins, improving their stability and transport to the brain.
- These engineered proteins successfully mimicked the effects of natural ligand-induced biological responses and showed enhanced brain accumulation in experimental models, suggesting potential for improved protein therapeutics.