Extraction of terminal ileal lipomas to cecum can facilitate endoscopic resection: A case series with video.

Large ileal lipomas over 2 cm can cause symptoms, that may require a resection. Due to the narrow lumen and thin walls of the ileum, endoscopic treatments can have a high risk of adverse events and require technical expertise, thus surgical resection is currently the mainstay of treatment. To overcome the technical challenges, we developed a novel method to endoscopically resect terminal ileal lipomas.

Transition of deformation modes from bending to auxetic compression in origami-based metamaterials for head protection from impact.

For the protection of the human head by energy absorption structures, a soft mechanical response upon contact with the head is required to mitigate the effect of impact, while a hard mechanical response for highly efficient energy absorption is required to stop the movement of the head. This study realized the opposite mechanical properties during head protection by transitioning the deformation mode from bending to auxetic compression. First, non-linear finite element (FE) models were constructed to numerically reproduce the bending behavior.

Mathematical model based on staircase structure for porous electrode impedance.

Mathematical models for porous electrode impedance have been widely used in energy conversion and storage. They are also utilized for obtaining the physicochemical dynamics, resulting in theoretical understanding and prediction in practical energy devices. The existing mathematical models are limited in their explanations.

Does Routine Follow-Up after Patients Have Completed Adjuvant Therapy for Early-Stage Breast Cancer at a Cancer Center Improve Prognosis?

Introduction: This study aimed to assess whether follow-up of patients with operative breast cancer at cancer centres (CCs) improved prognosis compared with follow-up by family physicians (FPs).

Methods: The study included 254 patients who relapsed within 7 years from the first postoperative period. The patients were divided into two groups according to the follow-up facility: the CC and FP groups (the follow-up of patients was structured in the same way between FPs and CCs).

Impact of Surface Layer Formation during Cycling on the Thermal Stability of the LiNiCoMnO Cathode.

In this study, the effects of charge/discharge cycling on the thermal stability of LiNiCoMnO, a high-Ni cathode material, are systematically investigated. X-ray diffraction measurements show that there is almost no change in the bulk structure of the cathode after cycling. However, X-ray absorption fine structure measurements indicate that Ni in the surface layer is reduced and stable rock-salt structures are formed.

[Resection of a Myxoma Orginating from the Coumadin Ridge with Superior Transseptal Approach:Report of a Case].

A 70-year-old man with a history of lacunar stroke about a year before was incidentally found to have primary cardiac tumor during the work up for orthopedic surgery. It uniquely originated from the coumadin ridge between the left upper pulmonary vein and the left atrial appendage. He underwent tumor resection under cardiopulmonary bypass with superior transseptal approach.

IgG4-related Dacryoadenitis and Sialadenitis with Palatal Gland Swelling.

Many cases of immunoglobulin G4-related disease (IgG4-RD) involve swelling of the salivary glands, often affecting the parotid and submandibular glands in the head and neck region, in addition to the lacrimal glands. Cases of IgG4-RD characterized by swelling of the palatal glands, however, are extremely rare. Here, we describe a case of IgG4-RD involving bilateral swelling of the palatal glands.

Temporary Closure of Inpatient Ward due to Mumps Virus Reinfection in Elderly Patient.

We report a case of suspected reinfection with the mumps virus in an elderly patient which resulted in temporary closure of an inpatient ward. A 65-year-old man with colorectal cancer was admitted to the digestive surgery ward at our hospital to undergo a stoma closure operation. He was subsequently referred to our department with right swelling in the preauricular region on postoperative day 4.

3D-Microbattery Architectural Design Optimization Using Automatic Geometry Generator and Transmission-Line Model.

Optimization of the 3D battery architecture is crucial to improve the performance of microbatteries. However, such optimization is difficult and time consuming by hand for even experts. In this article, we propose a battery optimization system, which consists of an automatic geometry generator and performance simulators.

Ultrasonographic changes associated with the healing process in a fracture of the distal phalanx in a cow.

A female Holstein cow presented with lameness in the left hind-limb, having suffered a fracture within the distal phalanx distal to the distal interphalangeal joint. The lesion was visualized as a radiolucent gap on a lateral radiograph and a hypoechoic gap on an ultrasonogram in which the hyperechoic bony line disappeared. Using regular ultrasonographic examinations, the healing of the fracture could be characterized by increased echogenicity inside the gap and the formation of a hyperechoic bony bridge.

Clinicopathological review of solitary fibrous tumors: dedifferentiation is a major cause of patient death.

Solitary fibrous tumor (SFT) is a soft-tissue neoplasm of intermediate malignant potential, presenting a wide histopathological spectrum. Poorer prognosis of hemangiopericytoma of the central nervous system (CNS), hypoglycemic SFT, and dedifferentiation are well-known characters of SFT, but their clinical significance were not demonstrated enough by large-sized study. Here, the clinicopathological features of SFTs are reviewed and the relationship between genetics and clinicopathological features is examined using 145 SFT cases.

Ion Transport in Porous Electrodes Obtained by Impedance Using a Symmetric Cell with Predictable Low-Temperature Battery Performance.

The decline of lithium-ion battery (LIB) performance at low temperatures, caused by the nonuniform occurrence of electrochemical reactions during cycling and the resulting irreversible capacity loss, significantly hinders further LIB commercialization. Herein, we report the first solution by analyzing the impedance using symmetric cells in the absence of charge-transfer reactions to obtain a parameter quantitatively describing ion transport in porous electrodes and thus modeling the effects of nonuniform reaction occurrence. The reciprocal of ionic resistance in porous electrodes () is found to be positively correlated with capacity retention during low-temperature cycling and is approximated as the product of maximum capacitance related to electric double-layer formation () and the associated frequency ().

Conservatively treated coronary malperfusion associated with acute type A dissection before aortic root replacement.

Coronary malperfusion associated with aortic dissection usually requires aggressive surgical treatment or catheter revascularization. Here, we report a case of conservatively treated coronary malperfusion associated with acute type A dissection before aortic root replacement. An 81-year-old woman was rushed to our hospital in a state of circulatory shock after developing chest pain.

The Use of CT-Guided Marking for the Laparoscopic Resection of a Solitary Retroperitoneal Metastasis of Colon Cancer.

CT-guided marking technique is rarely used in abdominal or urologic surgery. We developed and performed a marking technique for a small tumor, undetectable by ultrasound, using CT guidance before laparoscopic resection of the tumor. A 73-year-old woman with a history of breast cancer underwent right colectomy with D3 lymph node dissection for ascending colon cancer.

Ovarian Metastases from ALK-rearranged Lung Adenocarcinoma: A Case Report and Literature Review.

We herein report a 37-year-old woman with lung adenocarcinoma with brain metastases and an asymptomatic ovarian tumor. Immunohistochemistry and a fluorescent in situ hybridization analysis of the biopsied lung tumor revealed anaplastic lymphoma kinase (ALK) gene rearrangement. Although the origin of the ovarian tumor remained unclear, alectinib administration was initiated, and radiological responses were observed in all lesions, which confirmed that the ovarian tumor was a metastasis from lung cancer.

Abdominal aortic aneurysm with periaortic malignant lymphoma differentiated from aneurysmal rupture by clinical presentation and magnetic resonance imaging.

Abdominal aortic aneurysm (AAA) associated with periaortic malignant lymphoma is difficult to differentiate from aneurysmal rupture because of similarities in their clinical presentation and appearance on computed tomography images. We here report a case of AAA associated with periaortic malignant lymphoma diagnosed preoperatively with an absence of typical symptoms, showing that AAA in periaortic malignant lymphoma can present without any clinical correlates. Magnetic resonance imaging was used to confirm the diagnosis.

Effect of Propofol Continuous-Rate Infusion on Intravenous Glucose Tolerance Test in Dogs.

Hyperglycemia causes perioperative complications and many anesthetics impair glucose metabolism and cause hyperglycemia. We evaluated the effects of propofol on blood glucose metabolism and insulin secretion during an intravenous glucose tolerance test (IVGTT) in dogs. Blood glucose, insulin, triglyceride, cholesterol, and free fatty acid (FFA) levels were measured in dogs during IVGTT in a conscious state and under the effect of 2.

T-DNA Tagging-Based Gain-of-Function of OsHKT1;4 Reinforces Na Exclusion from Leaves and Stems but Triggers Na Toxicity in Roots of Rice Under Salt Stress.

The high affinity K⁺ transporter 1;4 (HKT1;4) in rice (), which shows Na⁺ selective transport with little K⁺ transport activity, has been suggested to be involved in reducing Na in leaves and stems under salt stress. However, detailed physiological roles of OsHKT1;4 remain unknown. Here, we have characterized a transfer DNA (T-DNA) insertion mutant line of rice, which overexpresses ;, owing to enhancer elements in the T-DNA, to gain an insight into the impact of OsHKT1;4 on salt tolerance of rice.

Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.

It has been hypothesized that selective inhibition of phosphodiesterase (PDE) 2A could potentially be a novel approach to treat cognitive impairment in neuropsychiatric and neurodegenerative disorders through augmentation of cyclic nucleotide signaling pathways in brain regions associated with learning and memory. Following our earlier work, this article describes a drug design strategy for a new series of lead compounds structurally distinct from our clinical candidate 2 (TAK-915), and subsequent medicinal chemistry efforts to optimize potency, selectivity over other PDE families, and other preclinical properties including in vitro phototoxicity and in vivo rat plasma clearance. These efforts resulted in the discovery of N-((1S)-2-hydroxy-2-methyl-1-(4-(trifluoromethoxy)phenyl)propyl)-6-methyl-5-(3-methyl-1H-1,2,4-triazol-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (20), which robustly increased 3',5'-cyclic guanosine monophosphate (cGMP) levels in the rat brain following an oral dose, and moreover, attenuated MK-801-induced episodic memory deficits in a passive avoidance task in rats.

[Metastasis of Hepatocellular Carcinoma to the Membrane of Chronic Subdural Hematomas:A Case Report].

An 81-year-old man presented with gait disturbance. Two months previously, he suffered from hepatocellular carcinoma and transarterial chemoembolization was performed. A head computed tomography(CT)scan revealed bilateral chronic subdural hematomas.

Association of beer consumption with arsenic concentration in urine: a result from a cross-sectional study of the general Japanese population.

Objectives: The first aim of this study was to evaluate the association between time spent living near a contaminated area and concentration of arsenic (As) compounds in the urine among study subjects. The second aim is to assess the association between consumption of various foods or beverages and As concentration in urine among them.

Methods: Urine sampling was performed on 177 persons who voluntarily participated in the survey in May 2014.

Altitude-Induced Pulmonary Hypertension on One-Day Rapid Ascent of Mount Fuji: Incidence and Therapeutic Effects of Sildenafil.

Aims: Exposure to high altitudes especially with rapid ascent may induce hypoxic pulmonary vasoconstriction (HPV) and pulmonary hypertension (PH) possibly leading to life-threatening high-altitude pulmonary edema (HAPE). The aim of the study was to evaluate the incidence of PH on a 1-day rapid ascent up Mount Fuji (3775 m) in recreational climbers and also to determine the effectiveness of sildenafil for this rapid ascent-induced PH as measured by echocardiography.

Methods And Results: Twenty-five subjects who climbed Mount Fuji showed significantly increased pulmonary artery systolic pressure (PASP) from 22.

Treatment strategy for bilateral carotid stenosis: 2 cases of carotid endarterectomy for the symptomatic side followed by carotid stenting.

Since the introduction of carotid stenting (CAS), a combined treatment for bilateral lesions using carotid endarterectomy (CEA) and CAS has been developed. However, there has been only 1 report about CEA then CAS. Herein we describe 2 patients with bilateral severe carotid stenosis who were treated by CEA for the symptomatic side and CAS for the contralateral asymptomatic side.

[A case of lateral ventricle metastasis from gastric carcinoma].

Metastatic brain tumors of the lateral ventricles are rare. Approximately half of the reported cases have originated from renal carcinoma;to the best of our knowledge, only 1 case originating from gastric carcinoma has been reported. A 57-year-old man presented with dull headache, left hemiparesis, and constructional apraxia of the right upper extremity.