Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents.

Diabetes mellitus is a serious global health concern, and this is expected to impact more than 300 million people by 2025. The current study focuses on identifying substituted indolin-2-one-based inhibitors for two indispensable drug targets, α-amylase and α-glucosidase. The structures of synthetic compounds were confirmed by spectroscopic techniques and evaluated for enzyme inhibition activities.