Publications by authors named "Itoe Shiota"
Background & Aims: Consistent with its relatively narrow host species range, hepatitis A virus (HAV) cannot infect C57BL/6 mice. However, in Mavs mice with genetic deficiency of the innate immune signaling adaptor MAVS, HAV replicates robustly in the absence of disease. The HAV 3ABC protease cleaves MAVS in human cells, thereby disrupting virus-induced IFN responses, but it cannot cleave murine MAVS (mMAVS) due to sequence differences at the site of scission.
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- * A study analyzed 1,070 stool samples from children with acute gastroenteritis in Japan and identified 76 positive cases of PeV-A, revealing five different genotypes, notably PeV-A1B as the most common.
- * The research highlighted significant genetic diversity of PeV-A in Japan and reported clinical symptoms including diarrhea, vomiting, fever, cough, and dehydration, alongside the first detection of the rare PeV-A2 genotype in the country.