Childhood maltreatment and the structural development of hippocampus across childhood and adolescence.

Background: Prior studies suggest that childhood maltreatment is associated with altered hippocampal volume. However, longitudinal studies are currently scarce, making it difficult to determine how alterations in hippocampal volume evolve over time. The current study examined the relationship between childhood maltreatment and hippocampal volumetric development across childhood and adolescence in a community sample.

Complete genome sequence of polylactic acid degrading strain R1 isolated from rice field soil.

R1 is a phototrophic, purple, non-sulfur Gram-negative bacterium first isolated from the soils of rice fields, known for its polylactic acid degradability. Here, we present the complete circular genome sequence of this bacterium, spanning 5.32 Mbp and 4,949 protein-coding sequences.

Interleukin-27 Regulates Adaptative Immune Responses Associated With Control of Parasite Replication in Canine Leishmaniasis.

Interleukin 27 (IL-27) is a cytokine that regulates susceptibility to Leishmania infantum infection in humans and experimental models. This cytokine has not yet been described in canine leishmaniasis (CanL). Therefore, we investigated whether IL-27 has a regulatory role in CanL.

Projections of non-exhaust emissions from brake wear across Japan for 2020-2050.

The concerns regarding the detrimental impacts of the increasing proportion of non-exhaust emissions are growing, even though there is a decrease in exhaust emissions from vehicles worldwide. Brake wear is a source of non-exhaust emissions. Despite the high density of traffic in Japan, the emission from brake wear has rarely been the target of studies.

Predicting the binding affinity of chemicals to estrogen receptor using Hansen solubility parameters.

Receptor-binding tests for the receptors of various substances are widely employed to identify drug candidates and predict the biological effects of chemical substances. Here, the results of chemicals binding to estrogen receptor (ER) reported in a validation study of the Organization for Economic Cooperation and Development TG 455 and the Hansen solubility parameter (HSP) values of the test substances were compared and examined using the Hansen sphere method, thus predicting potential HSPs that correspond to the ER-binding domain of agonists. Based on the results of the validation study and the HSP values of the test chemicals, a Hansen solubility sphere was created, and the ER potential parameter corresponding to the ER was obtained.

Which are the clinical consequences of Molar Incisor hypomineralization (MIH) in children and adolescents? Systematic review and meta-analysis.

Objective: This systematic review was conducted to address the following research question: "What are the clinical consequences (outcome) of Molar Incisor Hypomineralization (MIH) (exposure) in children and adolescents (population/patient)?".

Material And Methods: After defining the strategy, a search was performed in different databases (MEDLINE via Pubmed, Cochrane Library, BBO, LILACS, Scopus, Web of Science, Embase) and Grey literature in August 2023. Cross-sectional observational studies that identified clinical consequences of MIH (dental caries, post-eruptive structural loss, atypical restorations, hypersensitivity and tooth extraction) were included.

Exploring Neuroimaging Association Scores in adulthood ADHD and middle-age trajectories.

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder associated with brain differences in children, but not in adults. A combined evaluation of the regional brain differences could improve statistical power and, consequently, allow the detection of possible effects in adults. Thus, our aim is to verify whether Neuroimaging Association Scores (NAS) are associated with adulthood ADHD and clinical trajectories of the disorder in midlife.

Understanding of the role of serum creatinine in a subset of the Brazilian population.

Introduction: Chronic kidney disease is usually asymptomatic, and its diagnosis depends on laboratory tests, with emphasis on serum creatinine and proteinuria.

Objective: To assess knowledge on the role of serum creatinine as a biomarker of kidney function in a sample of the Brazilian population.

Method: Cross-sectional observational study conducted in São Paulo (SP, Brazil), in which a random adult population was interviewed.

Unveiling the peptidome diversity of Lachesismuta snake venom: Discovery of novel fragments of metalloproteinase, l-amino acid oxidase, and bradykinin potentiating peptides.

Snake venoms are known to be major sources of peptides with different pharmacological properties. In this study, we comprehensively explored the venom peptidomes of three specimens of Lachesismuta, the largest venomous snake in South America, using mass spectrometry techniques. The analysis revealed 19 main chromatographic peaks common to all specimens.

Risk assessment of chemical release accident triggered by landslide using Bayesian network.

This study evaluated the risk of 461,260,800 scenarios of chemical release accidents triggered by landslides. Several industrial accidents triggered by landslides have recently occurred in Japan; however, only a few studies have analyzed the impact of landslide-triggered chemical release accidents on the surrounding areas. Bayesian networks (BNs) have recently been used in the risk assessment of natural hazardtriggered technological accidents (Natech) to quantify uncertainties and develop methods applicable to multiple scenarios.

Reducing waste management scenario space for developing countries: A hierarchical clustering on principal components approach.

The complexity of waste management (WM) problems resulted in the explosion of scenarios that challenge focused discussion among stakeholders and hinder the integrity of policy responses in developing countries. Hence, drawing similarities is essential to reduce the number of scenarios to simplify the WM efforts. To extract similarities, measuring WM performance is not enough, but the background factors related to this performance should be incorporated.

CD73-Positive Cell Spheroid Transplantation Attenuates Colonic Atrophy.

The incidence of inflammatory bowel diseases (IBD) is increasing worldwide. Mesenchymal stem/stromal cells (MSCs) have immunomodulatory functions and are a promising source for cell transplantation therapy for IBD. However, owing to their heterogeneous nature, their therapeutic efficacy in colitis is controversial and depends on the delivery route and form of transplanted cells.

Health risk assessment and cost-benefit analysis of agricultural soil remediation for tailing dam failure in Jinding mining area, SW China.

The impact of the tailing dams and the economic feasibility of the remediation process is significant for future risk management for tailing dams. In this research, we develop a hypothetical failure scenario for a tailing dam in the Jinding mining area, Southwest China. We assess the exposure with the Geo-Environmental Risk Assessment System, tier-1 model, and health impact with Disability-Adjusted Life Years (DALY).

Prediction of acute oral toxicity using the Hansen solubility parameter.

Acute oral toxicity is primarily determined using animal testing, as stated in the Organization for Economic Cooperation and Development (OECD) Test Guideline (TG) 420, 423, and 425. Currently, regarding animal welfare, few alternatives to animal testing such as in vitro approaches have been evaluated. Therefore, in this preliminary study examining a new method to determine acute oral toxicity, we investigated whether UN Globally Harmonized System all categories can be predicted using the Hansen solubility parameter (HSP).

Food Insecurity and Malnutrition in Rural Tanzania: Mapping Perceptions for Social Learning.

In Tanzania, a high level of hunger persists. Several factors compound a complex scenario of food insecurity. Contextual aspects at the community level can influence the maintenance of the vulnerable local conditions.

Characterizing potential risk triggered by road traffic noise in comparison with typical air pollutants NO and PM.

Characterizing multiple risk stemming from automobiles are required from the viewpoint of priority setting for future risk management. However, little is known about such issues given the inadequacy of indicators. In this research, with the illustration of the metropolitan city of Osaka, Japan, using disability-adjusted life years (DALYs), impacts of road traffic noise and exhausts gas (nitrogen dioxide (NO) and particulate matter (PM)) were quantified and compared with the risks of ischemic heart disease and high sleep disturbance; and respiratory disease as endpoints, respectively.

An alternative predictor of eye irritation that utilizes potential parameters of the human corneal epithelium model calculated based on Hansen solubility parameters.

Eye irritation predictions are very important in the development of cosmetics and pharmaceuticals. For animal protection, alternative tests are being developed to replace the Draize test, which involves the use of rabbits to test eye irritation. The Vitrigel-eye irritancy test (Vitrigel-EIT), is one such alternative.

Highly accurate predictor of eye irritation utilizing potential parameters of a reconstructed human cornea epithelium model calculated based on Hansen solubility parameters.

Concerns regarding animal welfare have led to the need for alternatives to animal eye irritation tests. The reconstructed human cornea-like epithelium (RhCE) test is described in the OECD TG 492 as an alternative to animal eye irritation tests. However, the accuracy and labor investment of this method can be improved if the results can be predicted before the experiment.

Dental caries status of Lisu preschool children in Yunnan Province, China: a cross-sectional study.

Background: Dental caries is still considered a major public health concern for human beings, especially minority groups and those living in disadvantaged communities. The Lisu is a minority group in China of more than 702,000 people located primarily in Yunnan Province. The present study was aimed at studying the status of dental caries status, as well as its risk factors, among Lisu children aged 5 years in Yunnan Province, China.