Predominance of in candidemia among patients with solid tumor cancer in Oman: A retrospective study.

Objectives: species frequently cause bloodstream infections; however, there is a lack of epidemiological studies on candidemia in Oman.

Methods: To address this, we conducted a retrospective study at Sultan Qaboos Comprehensive Cancer and Research Center from October 2021 to October 2023.

Results: Our study identified 27 episodes of candidemia among 26 patients with cancer, with an incidence of 4.

A Rare Presentation of Recurrent Malignant Peripheral Nerve Sheath Tumor with Glandular Differentiation-A Case Report.

Malignant peripheral nerve sheath tumors (MPNST) are rare heterogeneous group of soft tissue neoplasms. In most cases, they originate within the pre-existing neurofibromatosis. The emergence of glandular structures in MPNST is curious and enigmatic.

Comparison of mortality in patients on chemotherapy or immunotherapy during and before COVID-19 pandemic. Multicenter matched cohort study in Argentina.

Objectives.: Motivation for the study. The impact of the COVID-19 pandemic on the risk of death in cancer patients on chemotherapy and immunotherapy is controversial.

Hypertensive Crisis in a Patient With a Functioning Mesenteric Paraganglioma: Dramatic Response to Octreotide Treatment.

Background/objective: To report a dramatic and immediate clinical and biochemical response during treatment with octreotide in a patient with a functioning mesenteric paraganglioma (PGL).

Case Report: A 44-year-old woman was admitted with a severe hypertensive crisis and a blood pressure reaching 260/150 mm Hg. She was 2 months postpartum and had been previously diagnosed with pre-eclampsia.

Malignant Gastrointestinal Neuroectodermal Tumor of Small Intestine Showing DOG1 Expression: A Case Report and Review of Literature.

Malignant gastrointestinal neuroectodermal tumor (GNET), also referred to as clear cell sarcoma-like tumor of the GI tract is a rare mesenchymal tumor of the gastrointestinal tract. It has to be distinguished from various mimickers including gastrointestinal stromal tumor (GIST) due to its aggressive course and different natural history and therapeutic approach. Here we report a case of GNET arising in the small intestine with aberrant DOG1 expression posing a diagnostic challenge.

Poly-microbial bacteremia in an immune-compromised patient.

(), a strict anaerobic gram-positive rod, is rarely reported in clinical specimens. Since its detection in 1899, it has always been linked to the decay of dead bodies. is considered non-pathogenic to humans, however infrequently it can cause severe infections including bacteremia.

Prevalence of HER2 overexpression and amplification in cervical cancer: A systematic review and meta-analysis.

The reported rates of HER2 positivity in cervical cancer (CC) range from 0% to 87%. The importance of HER2 as an actionable target in CC would depend on HER2 positivity prevalence. Our aim was to provide precise estimates of HER2 overexpression and amplification in CC, globally and by relevant subgroups.

New Treatments in Renal Cancer: The AhR Ligands.

Kidney cancer rapidly acquires resistance to antiangiogenic agents, such as sunitinib, developing an aggressive migratory phenotype (facilitated by c-Metsignal transduction). The Aryl hydrocarbon receptor (AhR) has recently been postulated as a molecular target for cancer treatment. Currently, there are two antitumor agent AhR ligands, with activity against renal cancer, that have been tested clinically: aminoflavone (AFP 464, NSC710464) and the benzothiazole (5F 203) prodrug Phortress.

Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis.

Background: Data on long-term prognosis of metastatic GCT (mGCT) is scant. The frequency of spontaneous regressions (SRs) is unknown. We aimed to estimate the prognosis of mGCT.

Aryl hydrocarbon receptor activation by aminoflavone: new molecular target for renal cancer treatment.

Aminoflavone (AF; NSC 686288, AFP464, NSC710464) is a new anticancer drug that has recently entered phase II clinical trials. It has demonstrated antiproliferative effects in MCF-7 human breast cancer cells mediated by the aryl hydrocarbon receptor (AhR). AF also exhibits noteworthy evidence of antitumor activity in vitro and in vivo against neoplastic cells of renal origin.

[Inability of large granular lymphocytes to recirculate through blood-lymph barriers].

The level of large granular lymphocytes (LGL) has been determined in thoracic lymph duct and peripheral blood of cattle. It has been shown that in contrast to the blood, these cells are present in the lymph in minor quantities. Unlike blood LGL, lymph LGL have smaller granules in cytoplasm.

[Mathematical simulation of the regulation of the size of the lymphoid population in relation to chronic lymphoid leukemia].

A model was constructed of accumulation kinetics of labeled lymphocytes based on the experiments of long-term injection of 3H-thymidine label in vivo into the blood of healthy and suffering from chronic lympholeucosis animals. There was found an essential difference between the coefficients of reproduction and death of cells of the proliferating pool for the normal, initial and advanced stages of the disease. This served as a basis for the creation of the closed non-linear model of autoregulation of lymphoid population size describing different stages of leucosis development.

[Comparative characteristics of lymphocyte proteolytic enzymes in normal conditions and in chronic lymphoid leukemia].

Proteolytic activity was estimated in lymphocyte lysates of cattle in normal state and in chronic lympholeukosis using 3H-acetylated casein (pH 7.4) and 3H-acetylated hemoglobin (pH 4.0) as substrates.

[Neutral glycolipids of the calf thymus and normal and leukemic bovine lymphocytes].

The composition and structure of the neutral glycolipids of calf thymus and of lymphocytes isolated from the blood, lymph, lymph nodes and spleen of normal and leukemic cows were investigated. The main neutral glycolipids of all lymphocytes studied were identified as glucosyl, lactosyl and digalactosylglucosylceramides. The relative amounts of these glycolipids were found to depend on lymphocyte localization.

Intensity of RNA synthesis in lymphocytes of different types of blood and lymph of cattle in the norm and during lymphoid leukosis.

It was established that in healthy animals the intensity of synthesis of quick-labeling RNA and also the percentage of small and medium labeled lymphocytes are substantially higher in the lymphocytes of lymph than in the lymphocytes of blood. The percentage of small blood lymphocytes doubles (from 25 to 50%) during leukosis, but is almost unchanged in lymph. For the majority of animals with leukosis, an increase of 5 to 10 times in the percentage of strongly labeled cells, including all types of lymphocytes, is characteristic.

Life span of lymphocytes in cattle in the norm and during lymphatic leukemia.

Comparison was made of the rate of in vivo elimination from blood and organs of cattle of lymphocytes labeled with 3H-thymidine in the course of seven days in the norm and during lymphatic leukemia. Significant delay in the elimination of labeled lymphocytes, and especially of lymphocyte precursors, from the blood, spleen, and lymph glands of the animal was established in the stage of lymphatic leukemia that was examined.

[Phospholipid composition of lymphocytes from normal and leukemic blood, lymph, lymph nodes and spleen of cattle].

The phospholipid composition and cholesterol content of lymphocytes from bovine blood, lymph, lymph-nodes and spleen were studied. The cholesterol/phospholipid molar ratio in the normal lymphocytes of blood and spleen was found to be about two times higher than that in the normal lymphocytes from lymph and lymph-nodes. On lymphocytic leukemia the cholesterol/phospholipid molar ratio of the blood lymphocytes decreased sharply, whereas that in lymph and lymph-nodes lymphocytes was unaffected.