Publications by authors named "Ithai Waldhorn"
Biological sex is a fundamental trait influencing development, reproduction, pathogenesis, and medical treatment outcomes. Modeling sex differences is challenging because of the masking effect of genetic variability and the hurdle of differentiating chromosomal versus hormonal effects. In this work we developed a cellular model to study sex differences in humans.
View Article and Find Full Text PDFIn the mammalian embryo, a formative pluripotent phase is proposed to exist at the early post-implantation period, during the transition from the pre-implantation naive-to the post-implantation primed-epiblast. By recapitulating a laminin component of the extracellular matrix niche during embryonic formative transition, and defined culture conditions, we generated cultures highly enriched for self-renewing human pluripotent stem cells (hPSCs), exhibiting properties of early post-implantation epiblast cells. These hPSCs display post-implantation-epiblast gene expression profiles.
View Article and Find Full Text PDFIt has been widely reported that women are underrepresented in leadership positions within academic medicine. This study aimed to assess trends in women representation as principal investigators (PIs) in oncology clinical trials and to characterize trends in women's leadership in such trials conducted between 1999 and 2019. The gender of 39,240 PIs leading clinical trials was determined using the gender prediction software Genderize.
View Article and Find Full Text PDFWe had previously reported short-term efficacy, immunogenicity, and safety of the BNT162b2 vaccine among cancer patients with solid tumors. We aimed to evaluate these outcomes at six months postvaccination. The study cohort comprised patients who were on treatment during vaccination and throughout six months postvaccination.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the psychological effects of the COVID-19 pandemic on cancer patients receiving intravenous treatment at a cancer center in Israel.
- It found that during the initial wave of the pandemic, a significant number of patients reported high distress levels, particularly those with pre-existing health conditions, and that this distress was linked to increased anxiety and depression later on.
- Patients with breast cancer expressed more distress compared to other cancer types, and feelings of loneliness and reduced family support were associated with higher anxiety levels, though depression was not similarly impacted.
Importance: The efficacy and safety profile of SARS-CoV-2 vaccines have been acquired from phase 3 studies; however, patients with cancer were not represented in these trials. Owing to the recommendation to prioritize high-risk populations for vaccination, further data are warranted.
Objective: To evaluate the use and safety of the BNT162b2 vaccine in patients undergoing treatment for cancer.