Publications by authors named "Italo Medeiros Azevedo"
Purpose: To examine the effects of a negatively charged nanostructured curcumin microemulsion in experimental ulcerative colitis (UC) in rats.
Methods: Four percent acetic acid was used to induce UC. The animals were treated for seven days and randomly assigned to four groups: normal control (NC), colitis/normal saline (COL/NS), colitis/curcumin (COL/CUR), and colitis/mesalazine (COL/MES).
Purpose: The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats.
Methods: Adult Wistar rats ( Rattus norvegicus ), weighing 227±35g, were allocated into a sepsis group by CLP (n=10) and sham group (n=10). 18F-FDG-PET using microPET was performed on all rats after 24 hours.
Purpose: The colon and ileum play significant roles on liver physiology. Studies about simultaneous hepatectomy and colectomy or enterectomy are scarce and controversial. We investigated and compared the effects of ileum and colon resection on liver regeneration.
View Article and Find Full Text PDFPurpose: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats.
Methods: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine.
Objective: simvastatin has pleiotropic anti-inflammatory and immunomodulatory effects potentially usefull to prevent chemotherapy-induced gastrointestinal mucositis. Studies on this are scarce. This study aimed to examine the effects of simvastatin on gastric and intestinal mucositis after 5-fluorouracil (5-FU) treatment in rats.
View Article and Find Full Text PDFPurpose: To evaluate if Moringa oleifera leaf aqueous extract (ME) influences the healing of skin wounds of diabetic rats.
Methods: Wistar rats were used (6 rats/group). Group 1 received normal saline (NS) v.
Objective: to evaluate whether colectomy, associated with 70% hepatectomy, influences liver regeneration in rats.
Methods: we distributed 18 Wistar rats in three groups of six animals each. In group I (sham), we performed laparotomy; In group II, colectomy + 70% hepatectomy; In group III, only 70% hepatectomy.
Purpose:: To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model.
Methods:: Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture.
To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performed Results: Better tissue perfusion was lower in ischemic left/kidney than in right/kidney in saline group, suggesting reduced kidney clearance. Fluorescence in left/kidneys of tadalafil treated rats was lower than in right/kidneys (difference not significant).
View Article and Find Full Text PDFPurpose:: To evaluate the effects of modified coconut water as fluid of resuscitation combined with simvastatin in hemorrhagic shock and sepsis model in rats.
Methods:: Four groups of Wistar rats with hemorrhagic shock and abdominal sepsis were studied (n=8/group). Rats were bled and maintained at a mean blood pressure 35mmHg for 60min.
Purpose: To investigate the antimicrobial, immunological and healing effects of Melipona scutellaris honey on infected wounds of rat skin.
Methods: Twenty four Wistar rats were distributed in four groups (6-each). The uninfected skin wounds of group I rats were treated daily with saline for 7 days.
Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition.
Acta Cir Bras
June 2015
Purpose: To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis.
Methods: Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.
Purpose: To test the hypothesis that liver regeneration after partial hepatectomy can be influenced by the ileum.
Methods: Eighteen Wistar rats were distributed into groups of six animals: 1 - ileum resection+ hepatectomy 2/3; 2 - hepatectomy 2/3, and 3 - sham. Anesthesia with ketamine and xylazine i.
Background: Assuming that ileal stimulation by food may increase incretin secretion, we aimed to investigate whether ileal interposition obtains adequate pancreatic islet viability and function after intramuscular islet transplantation in diabetic rats.
Methods: We investigated four groups of eight Wistar rats: ileal interposition + islet transplantation, islet transplantation, ileal interposition, and diabetic control. All rats were subjected to streptozotocin-induced diabetes.
Purpose: To investigate the influence of partial colectomy associated with hepatectomy on the biodistribution of the (99m)Tc-phytate, on metabolic parameters, as well as labeling and morphology of red blood cells.
Methods: Wistar rats were distributed into three groups (each with six), nominated as colectomy, colectomy+hepatectomy and sham. In the 30(th) postoperative day all rats were injected with (99m)Tc-phytate 0.
Background: The Roux-en-Y gastric bypass (RYGB) may affect metabolism, microbiology, and histology of gastric remnant. Therefore, this study aimed to investigate these issues in rats.
Methods: Twelve rats were randomly allocated to a RYGB group (n = 6) and nonoperated normal rats group (n = 6).
Purpose: To evaluate the effect of sildenafil, administered prior to renal ischemia/reperfusion (I/R), by scintigraphy and histopathological evaluation in rats.
Methods: Twenty-four rats were divided randomly into two groups. They received 0.
This study evaluated the effects of total colectomy on the biodistribution of technetium-99m pertechnetate ((99m)TcO(4)(-)) on the 28th postoperative day in rats. Samples of several organs were harvested for counting the percent of injected radioactivity/g of tissue (%ATI/g). The %ATI/g in colectomy rats was higher in the stomach and ileum than in sham and controls (p<0.
View Article and Find Full Text PDFThis paper investigates the influence of total gastrectomy, with and without a jejunal pouch, on the biodistribution of the radiopharmaceutical Technetium-99m pertechnetate ((99m)TcO(4)(-)). A quantitative biodistribution study was performed on the 30th postoperative day in Wistar rats, using the Wizard PerkinElmer gamma counter. The percentage of injected radioactivity of (99m)TcO(4)(-) per gram of tissue (% ATI/g) in Roux-en-Y total gastrectomy rats was lower in the lung, brain, and femur, compared to the sham rats (p <.
View Article and Find Full Text PDFObjective: Infection and sepsis are major causes of morbidity and mortality after surgery of diabetic patients. Statins have been shown to exhibit anti-inflammatory and immunomodulatory (pleiotropic) effects, independent of lipid lowering. This study aimed to observe whether the pretreatment with simvastatin in a cecal ligation and perforation model of sepsis is beneficial in diabetic rats.
View Article and Find Full Text PDFPurpose: Cyclophosphamide (CYP) is an antineoplastic agent used for the treatment of many neoplastic and inflammatory diseases. Hemorrhagic cystitis is a frequent side effect of CYP. Several studies show that simvastatin has important pleiotropic (anti-inflammatory and immunomodulatory) effects.
View Article and Find Full Text PDFPurpose: The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na(99m)Tc(-)) in organs and tissues of rats.
Methods: Twelve rats were randomly divided into two groups of 6 animals each.
Compensatory sweating after thoracoscopic sympathectomy: characteristics, prevalence and influence on patient satisfaction.
J Bras Pneumol
March 2009
Objective: This prospective study aimed at investigating predictive factors for compensatory sweating after thoracoscopic sympathectomy.
Methods: From 2000 to 2002, 80 patients (53 females and 27 males) underwent thoracoscopic sympathectomy to treat hyperhidrosis. Patient ages ranged from 12 to 56 years, and the mean post-operative follow-up period was 42.
Purpose: Many patients with metastatic bone disease have to use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of samarium-153-EDTMP in bones and other organs of rats.
Methods: Wistar male rats were randomly allocated into 2 groups of 6 rats each.
Purpose: To evaluate the biodistribution of sodium pertecnetate (Na(99m)TcO(4)) in organs and tissues, the morphometry of remnant intestinal mucosa and ponderal evolution in rats subjected to massive resection of the small intestine.
Methods: Twenty-one Wistar rats were randomly divided into three groups of 7 animals each. The short bowel (SB) group was subjected to massive resection of the small intestine; the control group (C) rats were not operated on, and soft intestinal handling was performed in sham rats.