Diacylphloroglucinol derivatives as antioxidant agents: green synthesis, optimisation, , and evaluation.

Several derivatives of diacylphloroglucinol ( and ) as an analogue of natural product compound 2,4-diacetylphloroglucinol , were successfully synthesised in an excellent yield a greener Friedel-Craft acylation using methanesulfonic acid (MSA) as a catalyst under an ultrasound-assisted condition. Operational simplicity, excellent yield, expedient metal-free synthesis, energy-efficient and mild reaction conditions are the outstanding advantages in this procedure. A scaled-up reaction also revealed the practical suitability of this newly developed procedure.