Publications by authors named "Istvan Szanda"
Computed tomography (CT) is one of the most widespread imaging techniques in clinical use worldwide. CT contrast agents are administered to improve soft tissue contrast and highlight blood vessels. However, the range of CT contrast agents available in the clinic is limited and they suffer from short-circulation times and low k-edge values that result in the need for high doses for in vivo applications.
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- Alzheimer's disease (AD) may disrupt the normal distribution of copper in the brain, which the study aimed to explore using PET imaging in mice.
- The researchers administered ionic copper and Cu-GTSM to TASTPM transgenic and wild-type mice, observing differences in how copper was taken up and cleared from various tissues over time.
- Findings indicated that copper dynamics in the brain were minimally altered in mice with AD-like pathology after copper acetate administration, whereas the Cu-GTSM showed more significant brain retention and potential for better understanding AD-related copper trafficking changes.
The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body imaging techniques such as positron emission tomography (PET). Thus, a broad method to radiolabel and track preformed nanomedicines such as liposomal drugs with PET radionuclides will have a wide impact in nanomedicine. Here, we introduce a simple and efficient PET radiolabeling method that exploits the metal-chelating properties of certain drugs (e.
View Article and Find Full Text PDFUnlabelled: Alzheimer disease (AD) is a fatal neurodegenerative disorder characterized by progressive neuronal loss and cognitive decline. The lack of reliable and objective diagnostic markers for AD hampers early disease detection and treatment. Growing evidence supports the existence of a dysregulation in brain copper trafficking in AD.
View Article and Find Full Text PDFThe motivations and methodology for high-throughput PET imaging of small animals in cancer research.
Eur J Nucl Med Mol Imaging
September 2012
Article Synopsis
- Small-animal PET imaging is super important for studying cancer and testing new treatments on animals.
- Researchers need to plan their experiments carefully so they can get good results and compare treated animals to control groups effectively.
- The paper talks about ways to improve imaging by using special setups that can scan multiple animals at once and explains some challenges that come up when imaging several animals together.
Unlabelled: The NanoPET/CT represents the latest generation of commercial preclinical PET/CT systems. This article presents a performance evaluation of the PET component of the system according to the National Electrical Manufacturers Association (NEMA) NU-4 2008 standard.
Methods: The NanoPET/CT consists of 12 lutetium yttrium orthosilicate:cerium modular detectors forming 1 ring, with 9.
Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent.
Angew Chem Int Ed Engl
June 2011
The polarization properties of light emitting diodes with integrated wire grid polarizers are investigated. Rigorous coupled wave analysis and Monte-Carlo ray tracing are used for modeling the gratings and the entire LED structure respectively. We show that it is more advantageous to place the polarizer onto the LED encapsulation rather than onto the die.
View Article and Find Full Text PDFPurpose: The human sodium/iodide symporter (hNIS) is a well-established target in thyroid disease and reporter gene imaging using gamma emitters (123)I-iodide, (131)I-iodide and (99m)Tc-pertechnetate. However, no PET imaging agent is routinely available. The aim of this study was to prepare and evaluate (18)F-labelled tetrafluoroborate ([(18)F]TFB) for PET imaging of hNIS.
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