Immune-mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy.

The objective of this article is to describe a case of suspected zonisamide-induced immune-mediated polyarthritis (IMPA) and anterior uveitis in a dog. A 7-year-old male neutered Siberian Husky with a history of refractory idiopathic epilepsy was presented for cluster seizures. Following the addition of zonisamide to the antiepileptic regime, the dog developed new IMPA and anterior uveitis.

5-Hydroxytryptophan toxicity successfully treated by haemodialysis in a dog.

Objective: To describe a case of 5-hydroxytryptophan (5-HTP) toxicity successfully treated with haemodialysis in a dog.

Case Summary: A 3-year-old, male neutered Labrador Retriever, weighing 28.2 kg, presented to the emergency department approximately 4-5 h after ingesting a human supplement containing 200 mg of 5-HTP.

A case of epiglottic entrapment in a cat.

Objective: The objective of this study was to describe a case of epiglottic entrapment in a cat.

Case Summary: A 5-month-old male neutered Russian Blue cat was evaluated for progressive stertorous upper airway sounds, acute onset vestibulopathy and abnormal laryngeal anatomy. Endotracheal intubation was only able to be achieved using videoscopic guidance and identified concern for severe nasopharyngeal stenosis.

Successful treatment of 5-fluorouracil toxicosis with hemodialysis.

Objective: To describe the successful treatment of lethal dose 5-fluorouracil (5-FU) toxicosis using hemodialysis.

Case Summary: A 4-month-old intact female Golden Retriever was presented to the emergency department after ingesting 20 g of 5% 5-FU cream. The puppy developed refractory seizures and became comatose with uncontrolled tonic-clonic convulsions.

Acute kidney injury from presumptive intramural ureteral hemorrhage secondary to diphacinone rodenticide exposure in a dog.

Objective: To describe the clinical features and outcome of a dog with anticoagulant rodenticide (diphacinone) exposure, which was subsequently diagnosed with a coagulopathy characterized by hemoperitoneum, and presumptive ureteral wall hemorrhage contributing to acute kidney injury (AKI).

Case Summary: A 4-year-old, female neutered Australian Cattle Dog was evaluated for an acute onset of lethargy, decreased appetite, and a mild right thoracic limb lameness. Radiographs and point of care ultrasound demonstrated retroperitoneal and peritoneal effusion.

Effects of storage and leukocyte reduction on the concentration and procoagulant activity of extracellular vesicles in canine packed red cells.

Objectives: To characterize the size and procoagulant activity of extracellular vesicles (EV) that accumulate in canine packed red blood cells (pRBCs) over time and the effect of leukocyte reduction on these characteristics.

Design: Prospective cohort study.

Setting: Private small animal specialty referral hospital and university research laboratories.

Pharmacokinetics and efficacy of trazodone following rectal administration of a single dose to healthy dogs.

Objective: To determine the pharmacokinetics and efficacy of trazodone following rectal administration of a single dose to healthy dogs.

Animals: 6 healthy adult dogs.

Procedures: Each dog received a single dose of trazodone (approx 8 mg/kg) per rectum.

Suspected Acute Respiratory Distress Syndrome Associated With the Use of Intravenous Lipid Emulsion Therapy in a Dog: A Case Report.

A 12-year-old male neutered Bichon Frise presented to the Emergency Department for stupor and bradycardia after ingestion of chocolate covered 450 mg (90 mg/kg) tetrahydrocannabinol. The patient was hospitalized for supportive care, IV fluid therapy and monitoring in the intensive care unit. During hospitalization the patient became comatose and bradypneic.

Presumptive intraperitoneal envenomation resulting in hemoperitoneum and acute abdominal pain in a dog.

Objective: To describe the clinical features, diagnostic findings, treatment, and outcome of a dog with acute abdominal pain and hemoperitoneum secondary to a presumptive intraperitoneal (IP) snakebite.

Case Summary: A 10-month-old castrated male mixed-breed dog was evaluated for suspected snake envenomation. The dog presented recumbent and tachycardic with signs of severe abdominal pain.

Systematic evaluation of evidence on veterinary viscoelastic testing part 4: Definitions and data reporting.

Objective: To systematically examine evidence surrounding definitions and reporting of data for viscoelastic testing in veterinary medicine.

Design: Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice.

Setting: Academic and referral veterinary medical centers.

Evaluation of a point-of-care anticoagulant rodenticide test for dogs.

Objective: To evaluate a point-of-care anticoagulant rodenticide lateral flow analyzer for the detection of various rodenticide compounds.

Design: Prospective, laboratory study.

Setting: University teaching hospital.

[A naturalistic, observational study of outpatients with schizophrenia: efficacy and safety results after 6 months. The International Schizophrenia Outpatient Health Outcomes study, IC-SOHO].

The International Schizophrenia Outpatient Health Outcomes study, IC-SOHO is a three-year international observational study that investigates clinical and health outcomes of antipsychotic treatments. 7658 outpatients treated for schizophrenia were enrolled in the study, who needed an antipsychotic therapy to initiate or switch. The primary analysis compared the group taking olanzapine with the group taking any other antipsychotics, while the secondary comparison was performed between those treated with olanzapine and those with risperidone.

[Pharmacokinetics of ipriflavone].

Ipriflavone administered to rats orally is well absorbed from small intestine via the portal route, distributed widely in tissues, metabolized extensively by oxidation, and eliminated from the body preferentially in urine. The absorption of ipriflavone is less effective in dogs, than in rats. In dogs, the compound absorbed is metabolized in the same way as in rats and the metabolites formed are eliminated largely in faeces, together with unabsorbed ipriflavone.

[Metabolism of ipriflavone].

Ipriflavone is intensively metabolized by the organism, due to strong first-pass metabolism only a small fraction of the dose absorbed is unchanged Ipriflavone. Seven metabolites were identified in animal as well as in human studies. Ipriflavone is metabolized exclusively in the liver by elimination, or oxidation of the isopropyl group and hydroxylation of the beta-ring followed by conjugation with glucuronic and/or sulphuric acid.