[Historical data on the beginning of the education of the subject "Surgical anatomy and operative techniques" at the time of Founding of the institute in Debrecen •].

On December 1, 1951, the Institutes of Surgical Anatomy and Operative Techniques were founded in Hungary. In the academic year 1951/1952, only lectures were held for the students, in an increased number of hours during the semester, there was no practical opportunity yet due to the structural organization of the institutes. The actual teaching of the subject only started in the academic year 1952/1953 for the fourth year (semester 8-9) in the form of 1 h of lecture and 2 h of practical training per week, for a total of 40 h per semester.

[Historical data on the Founding of Experimental Surgical Section of the Hungarian Surgical Society].

Following the establishment of the European Society for Surgical Research - ESSR on February 17, 1966 in Nancy/France. After the Re-establishment of Hungarian Surgical Society the organization of the Experimental Surgical Section of the Hungarian Surgical Society also started in October 1966. By January 25, 1967, there were 134 registered members of the Section.

Experiences with basic microsurgical training programs and skill assessment methods at the University of Debrecen, Hungary.

During the past decades microsurgical training programs together with skill assessment methods had been developing intensively worldwide. Concerning the teaching of basic techniques at various levels, we aimed to summarize the education program types and experiences at our department, in order to define the way of continuity. All in the hope that this summary might contain useful information for other educators as well.

Defining Standards in Experimental Microsurgical Training: Recommendations of the European Society for Surgical Research (ESSR) and the International Society for Experimental Microsurgery (ISEM).

Background: Expectations towards surgeons in modern surgical practice are extremely high with minimal complication rates and maximal patient safety as paramount objectives. Both of these aims are highly dependent on individual technical skills that require sustained, focused, and efficient training outside the clinical environment. At the same time, there is an increasing moral and ethical pressure to reduce the use of animals in research and training, which has fundamentally changed the practice of microsurgical training and research.

How does practice improve the skills of medical students during consecutive training courses?

Purpose:: To follow-up the development of medical students in taking a stitch using two different bench models, and to assess their performance with regards to gender, handedness, prior recreational activities and interest in surgery.

Methods:: The study was performed during the compulsory basic (n=152) and the consecutive elective course (n=27). Students took simple interrupted stitches into synthetic and biopreprate models in the classroom and in the operating room.

Changes of red blood cell aggregation parameters in a long-term follow-up of splenectomy, spleen-autotransplantation and partial or subtotal spleen resections in a canine model.

Background: Decrease or loss in splenic filtration function may influence the hemorheological state.

Objective: To follow-up the long-term effects of splenectomy, spleen autotransplantation and spleen resections on red blood cell aggregation in a canine model.

Methods: Beagle dogs were subjected to control (n = 6), splenectomy (SE, n = 4), spleen autotransplantation (AU, Furka's spleen-chip method, n = 8) or partial and subtotal spleen resection (n = 4/each) groups, and followed-up for 18 postoperative (p.

Comparative erythrocyte deformability investigations by filtrometry, slit-flow and rotational ektacytometry in a long-term follow-up animal study on splenectomy and different spleen preserving operative techniques: Partial or subtotal spleen resection and spleen autotransplantation.

Background: Partial or subtotal spleen resection or spleen autotransplantation can partly preserve/restore the splenic filtration function, as previous studies demonstrated.

Objective: For better evaluation and follow-up of the various spleen-preserving operative techniques' effectiveness versus splenectomy, a composite methodological approach was applied in a canine experimental model.

Methods: Beagle dogs were subjected to control (n = 6), splenectomy (SE, n = 4), partial and subtotal spleen resection (n = 4/each) or spleen autotransplantation groups (AU, Furka's spleen-chip method, n = 8).

Intra and postoperative evaluations of microcirculation and micro-rheological parameters in a rat model of musculocutaneous flap ischemia-reperfusion.

Purpose: To examine how the ischemia-reperfusion injury of latissimus dorsi-cutaneous maximus (LDCM) musculocutaneous flap affects the microcirculatory (flap's skin surface) and hemorheological parameters, and whether an intraoperative deterioration would predictively suggest flap failure in the postoperative period.

Methods: Ten healthy male rats were subjected to the study. In Group I the left flap was sutured back after 2-hour, while the contralateral side was right after its elevation.

Usage of ultraviolet test method for monitoring the efficacy of surgical hand rub technique among medical students.

Background: Adequate hand movements are essential in surgical hand rub, so it is important for medical students to learn it correctly. To assess its efficacy, we aimed to use ultraviolet (UV) light test after applying fluorescent solution.

Methods: Digital images of the hands of 253 medical students were analyzed during "Basic Surgical Techniques" course on the 10th (Survey 1) and 14th (Survey 2) week of the curriculum to check the process and the skills development.

[Trocar site herniation (TSH) following laparoscopic cholecystectomy: incidence, pathogenesis, and prevention -- animal study].

Introduction: In 1968 R. E. Fear first reported a trocar site hernia (TSH) in his large series on laparoscopy.

A modified microsurgical model for end-to-side selective portacaval shunt in the rat. Intraoperative microcirculatory investigations.

Purpose: To investigate the intraoperative microcirculatory changes of the affected organs (small bowel, liver and kidney) during the making of a modified selective portacaval (PC) shunt.

Methods: On ten anaesthetized Sprague-Dawley rats the selective end-to-side mesocaval anastomosis was performed, where only the rostral mesenteric vein is utilized and the portal vein with the splenic vein are left intact. Morphometric and microcirculatory investigations using a LDF device determining flux units (BFU) were carried out.

[Main indicators of educational activity at the Department of Operative Techniques and Surgical Research at the University of Debrecen between 2000-2013].

The authors provide a review about the main parameters of the gradual and postgradual educational activity of the Department of Operative Techniques and Surgical Research between 2000-2013. In this period of time several new subjects and courses have been introduced. The thematics have been widened, and the educational topics underwent a significant change and development: new teaching videos, revised note-books and a new textbook have been prepared through these years.

[Hemorheological investigations in experimental surgery].

The hemorheological parameters, such as whole blood viscosity, plasma viscosity, hematocrit, fibrinogen concentration as well as the micro-rheological properties of red blood cells (red blood cell deformability and aggregation) play an important role in tissue perfusion. The alternating hemorheological parameters, which are also inter-related, have important effects in determining hemodynamical properties, as well. The altered hemorheological status has a direct effect on endothelial function by changing shear force profile on the endothelial wall, and impairment of red blood cell deformability and aggregation (presence of rigid red blood cell, and enhanced red blood cell aggregation) slows down microcirculation with disturbing capillary perfusion.

[The spleen in experimental surgery].

The injured but functionally intact spleen can be saved with various surgical techniques. Two of these techniques were developed in our department: partial spleen resection by embracing suture line, and spleen autotransplantation by implantation of spleen chips between the sheets of the greater omentum, the so called "spleen-apron" technique. Functional and structural postsurgical follow-up investigations were developed in the last three decades, including comprehensive laboratory tests (hematological, hemostaseological, hemorheological, enzymological, routine chemical, immunological), imaging procedures (abdominal US, scintigraphic methods, SPECT, as well as NanoSPECT/CT in the last years) with morphological analysis (conventional histological, immunohistochemical, electonmicroscopical), as well as the investigation of the role of hemopoetic stem cells.

Simultaneous investigation of hemodynamic, microcirculatory and arterio-venous micro-rheological parameters in infrarenal or suprarenal aortic cross-clamping model in the rat.

We aimed to investigate hemodynamic, microcirculatory and hemorheological consequence of infrarenal or suprarenal aortic cross-clamping (IRAXC, SRAXC) in the rat. We hypothesized that the magnitude of the changes are different. Twenty-one male rats were randomized into Control, IRAXC or SRAXC groups.

Effects of various drugs (flunixin, pentoxifylline, enoxaparin) modulating micro-rheological changes in cerulein-induced acute pancreatitis in the rat.

Previously we have investigated the cerulein-induced acute pancreatitis and provided data on its micro-rheological impact in the rat. We hypothesized that non-steroid anti-inflammatory agent flunixin, the xanthine-derivate pentoxifylline and the low molecular weight heparin enoxaparin may have various beneficial effects improving microcirculatory and rheological parameters. In female rats, under general anesthesia, 10 μg/kg cerulein s.

Hemorheological changes in ischemia-reperfusion: an overview on our experimental surgical data.

Blood vessel occlusions of various origin, depending on the duration and extension, result in tissue damage, causing ischemic or ischemia-reperfusion injuries. Necessary surgical clamping of vessels in vascular-, gastrointestinal or parenchymal organ surgery, flap preparation-transplantation in reconstructive surgery, as well as traumatological vascular occlusions, all present special aspects. Ischemia and reperfusion have effects on hemorheological state by numerous ways: besides the local metabolic and micro-environmental changes, by hemodynamic alterations, free-radical and inflammatory pathways, acute phase reactions and coagulation changes.

Testicular ischemia-reperfusion may alter micro-rheological parameters in laboratory rats.

Ischemia-reperfusion-caused hemorheological alterations have been widely studied but the effect of testicular ischemia-reperfusion has not so far. In this study 14 Sprague-Dawley rats were involved. In the ischemia-reperfusion group under general anaesthesia the left testis was explored by opening the scrotum then the deferent duct and vasculature were clamped for 30 minutes.

Long-term following-up of viability of spleen autotransplants in the Beagle canine model.

Purpose: To examine the possible late complications of splenectomy or spleen autotransplantation in large laboratory animal model, in which we need non-invasive or minimal-invasive methods for long-term monitoring of the experimental animals.

Methods: Experimental groups of beagle dogs were: non-operated control, sham-operated control, splenectomy, spleen autotransplantation with 5 or 10 spleen-chips taken into the greater omentum (Furka's technique). Prior to operations, on the 1(st) postoperative week, monthly till the 6(th) as well as in the 9(th) and 12(th) month, hemorheological examinations were performed.

Micro-rheological changes during experimental acute pancreatitis in the rat.

Although microcirculatory disturbances play pivotal role in the pathomechanism of acute pancreatitis (AP), very few papers can be found which had been tested any of hemorheological parameters. The aim of our study was to analyze the hemorheological changes in cerulein-induced experimental acute pancreatitis in rat in two doses (5 and 10 μg/kg, s.c.

Concerning the importance of changes in hemorheological parameters caused by acid-base and blood gas alterations in experimental surgical models.

Acid-base equilibrium and pH of blood have important clinical consequences in numerous diseases and pathophysiological conditions. The micro-rheological parameters of blood, such as red blood cell deformability and red blood cell aggregation are influenced by several metabolic factors, and provide information regarding inflammatory, septic and tissue or organ ischemia-reperfusion processes. Despite the anticipated logical relation of the blood acid-base condition, blood gas parameters and pH to red blood cell deformability and aggregation, controversial data can be found in the literature.