Publications by authors named "Issaka Seidou"
Article Synopsis
- Pneumococcal meningitis in the African meningitis belt is mainly caused by Streptococcus pneumoniae serotype 1, which is targeted by the 13-valent pneumococcal conjugate vaccine (PCV13) introduced in Niger in 2014.
- A study analyzing data from a national reference laboratory showed a significant decline in vaccine-type (VT) serotypes of S. pneumoniae in children under 5 years after the introduction of PCV13, from 74.0% to 28.1%.
- Despite the overall reduction in VT cases, serotype 1 continues to be the most prevalent cause of pneumococcal meningitis in older children and adults, highlighting the need for
Article Synopsis
- - In 2010, Niger implemented a new vaccine for meningitis, leading to a study analyzing bacterial meningitis cases from 2010 to 2018, confirming 5590 cases out of over 21,000 suspected.
- - The main bacteria found were Neisseria meningitidis (85%), Streptococcus pneumoniae (13%), and Haemophilus influenzae (2%), with no cases of NmA reported after 2011.
- - The patterns of meningitis serogroups changed over time, indicating the necessity for ongoing surveillance to adapt vaccine strategies effectively in Niger.
Background: To combat Neisseria meningitidis serogroup A epidemics in the meningitis belt of sub-Saharan Africa, a meningococcal serogroup A conjugate vaccine (MACV) has been progressively rolled out since 2010. We report the first meningitis epidemic in Niger since the nationwide introduction of MACV.
Methods: We compiled and analysed nationwide case-based meningitis surveillance data in Niger.
Neisseria meningitidis (Nm), Haemophilus influenzae (Hi), and Streptococcus pneumoniae (Sp) are the lead causes of bacterial meningitis. Detection of these pathogens from clinical specimens using traditional real-time PCR (rt-PCR) requires DNA extraction to remove the PCR inhibitors prior to testing, which is time consuming and labor intensive. In this study, five species-specific (Nm-sodC and -ctrA, Hi-hpd#1 and -hpd#3 and Sp-lytA) and six serogroup-specific rt-PCR tests (A, B, C, W, X, Y) targeting Nm capsular genes were evaluated in the two direct rt-PCR methods using PerfeCTa and 5x Omni that do not require DNA extraction.
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