Background: Radiation absorbed dose to the red bone marrow, in the therapy of differentiated thyroid carcinoma (DTC) with 131I (radioiodine), cannot be measured directly. The absorbed dose to the blood seems to be a good first- order approximation of the radiation absorbed dose to the hematopoietic system and a better means to quantify exposure from therapy than the total amount of activity administered.
Objective: The aim of this research was to determine the radiation absorbed dose to the blood, for patients suffering from differentiated thyroid cancer.
The visualization of a lesion depends on the contrast between the lesion and surrounding background (T/B; (target/background) ratio). For imaging in vivo not only is the radioactivity in the target organ important, but so too is the ratio of radioactivity in the target versus that in the background. Nearly all studies reported in the literature have dealt with the surface index, as a standard factor to study the relationship between the target (tissue or organ) and the background.
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