Investigation of the Importance of Applying Various Methods of Calculation in Determining the Blood-Absorbed Dose for Patients with Differentiated Thyroid Carcinoma.

The objective was to compare estimated total blood-absorbed doses obtained by applying 4 methods to the same group of patients. In addition, these results were compared with those for the patients of other researchers, who used various other techniques over a period of more than 20 y. Twenty-seven patients (22 women and 5 men) with differentiated thyroid carcinoma were enrolled in the study.

An indirect high iodine ( I) effective dose used for thyroid ablation in patients with thyroid cancer. Is the method of measurement important?

Background: Radiation effective dose to the red bone-marrow, a critical organ in the therapy of differentiated thyroid carcinoma (DTC) with radioiodine-131 ( I), cannot be measured directly. As radioiodine concentration is comparable in blood and most organs, and is believed to be similar in red marrow, the effective dose to the blood seems to be a good first-order approximation of the radiation effective dose to the hematopoietic system and a better means to quantifying exposure from therapy compared to the total amount of activity administered.

Purpose: We applied four formulas (Lassmann et al (standard) [2008], Eur J Nucl Med Molecul Imaging, 35:1405-1412), (Thomas et al.

Determination and Comparison of Radiation Absorbed dose to the Blood, by Applying Different Techniques, for Patients, Suffering from Differentiated Thyroid Cancer.

Background: Radiation absorbed dose to the red bone marrow, in the therapy of differentiated thyroid carcinoma (DTC) with 131I (radioiodine), cannot be measured directly. The absorbed dose to the blood seems to be a good first- order approximation of the radiation absorbed dose to the hematopoietic system and a better means to quantify exposure from therapy than the total amount of activity administered.

Objective: The aim of this research was to determine the radiation absorbed dose to the blood, for patients suffering from differentiated thyroid cancer.

A comparison of deconvolution and the Rutland-Patlak plot in parenchymal renal uptake rate.

Introduction: Deconvolution and the Rutland-Patlak (R-P) plot are two of the most commonly used methods for analyzing dynamic radionuclide renography. Both methods allow estimation of absolute and relative renal uptake of radiopharmaceutical and of its rate of transit through the kidney.

Materials And Methods: Seventeen patients (32 kidneys) were referred for further evaluation by renal scanning.

Comparison between the values of the hepatic uptake rate obtained by 2 methods, using hepatobiliary scintigraphy in patients with nonalcoholic steatohepatitis.

Unlabelled: (99m)Tc-mebrofenin hepatobiliary scintigraphy has been introduced for the noninvasive assessment of liver function in the clinical setting and in experimental research.

Methods: During a period of 2 y, 15 patients with fatty livers diagnosed as having nonalcoholic steatohepatitis underwent hepatobiliary scintigraphy using the radiopharmaceutical agent (99m)Tc-labeled mebrofenin. After intravenous administration of 85 MBq of (99m)Tc-mebrofenin, a dynamic image was acquired with the liver and heart in the field of view.

Qualitative values of radioactivity, area and volumetric: application on phantoms (target and background).

The visualization of a lesion depends on the contrast between the lesion and surrounding background (T/B; (target/background) ratio). For imaging in vivo not only is the radioactivity in the target organ important, but so too is the ratio of radioactivity in the target versus that in the background. Nearly all studies reported in the literature have dealt with the surface index, as a standard factor to study the relationship between the target (tissue or organ) and the background.

Radioprotection using iodine-131 for thyroid cancer and hyperthyroidism: a review.

Radioiodine (iodine-131, or I-131) therapy has been used successfully for thyroid therapy for more than 50 years. Protocols for treatment with I-131 differ from country to country and even from hospital to hospital in the same country. Daily area surveys of hallways, stairwells, and rooms adjacent to isolation rooms must be conducted and documented to ensure that doses to any individuals in unrestricted areas do not exceed 20 mcSv (2 mrem) in one hour.