Publications by authors named "Israt Islam"
Article Synopsis
- Multidrug-resistant (MDR) Acinetobacter baumannii is a significant concern in Bangladeshi healthcare due to its link with hospital-acquired infections, as highlighted by the study of a carbapenem-resistant strain, BD20, from an infected wound.
- The isolate showed resistance to nearly all antibiotics tested, except colistin and polymyxin B, and carried multiple antibiotic resistance genes alongside virulence factors, indicating its potential for increased harm.
- The study stresses the importance of ongoing surveillance and infection-control strategies in healthcare facilities to combat the challenges posed by MDR A. baumannii.
Article Synopsis
- The rising antimicrobial resistance in Providencia stuartii, especially in immunocompromised and burn patients in Bangladesh, necessitates urgent investigation, as this pathogen was previously underrecognized.
- Two strains isolated from critically injured burn patients displayed multidrug resistance, with one strain resistant to all 22 tested antibiotics and showing concerning genetic features linked to carbapenem resistance.
- A comprehensive genome-wide analysis revealed significant genetic diversity and resistance gene prevalence within P. stuartii, raising public health concerns about its adaptability and potential for cross-species transmission.
Article Synopsis
- The study focuses on the extensively drug-resistant strain of Pseudomonas aeruginosa isolated from a burn wound, highlighting its role in severe infections.
- Whole genome sequencing was performed to analyze the strain's genomic features, including its resistance to 14 antibiotics and various virulence factors.
- The research identifies this strain as the first extensively drug-resistant ST 357 P. aeruginosa reported from Bangladesh, indicating a need for further investigation into high-risk clones in the region.*
The multifactorial nature of Pseudomonas aeruginosa biofilm development and genomic variabilities implicates its resistance to conventional antimicrobials and virulence. Therefore, genetic determinants need to be extensively studied to block the early steps of biofilm or already formed biofilms. In this study, a total of 20 multidrug resistant (MDR) clinical P.
View Article and Find Full Text PDFBangladesh is experiencing a second wave of COVID-19 since March 2021, despite the nationwide vaccination drive with ChAdOx1 (Oxford-AstraZeneca) vaccine from early February 2021. Here, we characterized 19 nasopharyngeal swab (NPS) samples from COVID-19 suspect patients using genomic and metagenomic approaches. Screening for SARS-CoV-2 by reverse transcriptase polymerase chain reaction and metagenomic sequencing revealed 17 samples of COVID-19 positive (vaccinated = 10, nonvaccinated = 7) and 2 samples of COVID-19 negative.
View Article and Find Full Text PDFAlong with intrinsic evolution, adaptation to selective pressure in new environments might have resulted in the circulatory SARS-CoV-2 strains in response to the geoenvironmental conditions of a country and the demographic profile of its population. With this target, the current study traced the evolutionary route and mutational frequency of 198 Bangladesh-originated SARS-CoV-2 genomic sequences available in the GISAID platform over a period of 13 weeks as of 14 July 2020. The analyses were performed using MEGA X, Swiss Model Repository, Virus Pathogen Resource and Jalview visualization.
View Article and Find Full Text PDFThe novel coronavirus infectious disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has traumatized the whole world with the ongoing devastating pandemic. A plethora of microbial domains including viruses (other than SARS-CoV-2), bacteria, archaea and fungi have evolved together, and interact in complex molecular pathogenesis along with SARS-CoV-2. However, the involvement of other microbial co-pathogens and underlying molecular mechanisms leading to extortionate ailment in critically ill COVID-19 patients has yet not been extensively reviewed.
View Article and Find Full Text PDFThe ongoing mutations in the structural proteins of SARS-CoV-2 are the major impediment for prevention and control of the COVID-19 disease. Presently we focused on evolution of the envelope (E) protein, one of the most enigmatic and less studied protein among the four structural proteins (S, E, M and N) associated with multitude of immunopathological functions of SARS-CoV-2. In the present study, we comprehensively analyzed 81,818 high quality E protein sequences of SARS-CoV-2 globally available in the GISAID database as of 20 August 2020.
View Article and Find Full Text PDFThe emerged novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a global health crisis that warrants an accurate and detailed characterization of the rapidly evolving viral genome for understanding its epidemiology, pathogenesis, and containment. Here, we explored 61,485 sequences of the nucleocapsid (N) protein, a potent diagnostic and prophylactic target, for identifying the mutations to review their roles in real-time polymerase chain reaction based diagnosis and observe consequent impacts. Compared to the Wuhan reference strain, a total of 1034 unique nucleotide mutations were identified in the mutant strains (49.
View Article and Find Full Text PDFIntroduction: Effective sanitation strategies for poultry farms require an appropriate selection of the disinfectant based on the contaminants present and their sensitivity to the disinfectants.
Aim: The current study investigated the prevalence of streptococci/micrococci in poultry farms of Bangladesh and the efficacy of commercial disinfectants (Savlon, Lysol, Quatovet, Virkon S, and Virocid) along with alcohol against these pathogens to adopt appropriate strategies.
Materials And Methods: Conventional approaches and the 16S rRNA gene sequencing were performed to confirm the isolates at the species level along with microtiter biofilm assay to determine their biofilm-forming ability.