Publications by authors named "Israini Wiyulanda Iskandar"
Development of itraconazole ocular delivery system using β-cyclodextrin complexation incorporated into dissolving microneedles for potential improvement treatment of fungal keratitis.
J Biomater Sci Polym Ed
October 2024
Article Synopsis
- * Researchers created an inclusion complex (ITZ-IC) using β-cyclodextrin (β-CD), which significantly increased ITZ's solubility by 4-fold and confirmed stable binding through molecular docking studies.
- * A dissolving microneedle (DMN) system was developed for ocular delivery of ITZ-IC, showing good mechanical properties, rapid dissolution, 75.71% permeation through corneas, and no irritation, indicating a safe and effective delivery method.
Sildenafil citrate (SIL) as a first-line treatment for erectile dysfunction is currently reported to have poor solubility and bioavailability. Moreover, SIL undergoes first-pass metabolism when taken orally and its injection can lead to discomfort. In this study, we introduce a novel transdermal delivery system that integrates hydrogel-forming microneedles with the inclusion complex tablet reservoir.
View Article and Find Full Text PDFApplication of Biomaterials in the Development of Hydrogel-Forming Microneedles Integrated with a Cyclodextrin Drug Reservoir for Improved Pharmacokinetic Profiles of Telmisartan.
ACS Biomater Sci Eng
March 2024
Article Synopsis
- * The study developed a novel hydrogel-forming microneedle system combined with a tablet-like reservoir (HFMN-DCT) to enhance the transdermal delivery of TEL, utilizing materials like PVP, PVA, and tartaric acid.
- * Results showed that the new system improved the solubility and release of TEL significantly, demonstrated good mechanical properties, did not cause skin irritation, and performed well in both lab studies and tests on rats, indicating its potential for effective transdermal drug delivery.
Background: Studies on miRNA highlight its significance as an immunomarker for several diseases, including tuberculosis. This study aimed to determine the difference between miR-425-5p and miR-4523 expressions in patients with active pulmonary TB (PTB), latent TB infection (LTBI), and lymph node TB (LNTB), whose diagnosis remains challenging.
Methods: This case-control study was performed on blood samples obtained from 23 patients with PTB, 21 with LTBI, 21 with LNTB, and 25 healthy controls (HC).
The COVID-19 disease is a major problem affecting human health all over the world. Consequently, researchers have been trying to find solutions to treat this pandemic-scale disease. Even if there are vaccines and approved drugs that could decrease the spread of this pandemic, multidisciplinary approaches are still needed to identify new small molecules as alternatives to combat COVID-19, especially those from nature.
View Article and Find Full Text PDFThe respiratory infection COVID-19 caused by the virus SARS CoV-2 has continued to be a major health problem worldwide and has caused more than a million mortalities. Even if the development of COVID-19 vaccines has shown much progress, efforts to find novel, natural anti-viral drugs should be pursued. is a marine red alga widely distributed around Southeast Asia.
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