Publications by authors named "Israel Kremer"
Article Synopsis
- The eyelids, eyelashes, conjunctival fornices, and lacrimal system are crucial for maintaining eye health, and any abnormalities in these areas can lead to ocular surface diseases.
- The text discusses how oculoplastic surgery can help treat various conditions related to the eyelids and surrounding structures, such as blink disorders, lagophthalmos (inability to close the eyes), and entropion (inward turning of the eyelid).
- Additionally, it addresses issues like lid scarring, keratinization, trichiasis (misdirected eyelashes), and diseases affecting the punctal and lacrimal sac that can affect tear drainage and overall eye health.
Article Synopsis
- Corneal melting and perforation can occur in autoimmune disorders like rheumatoid arthritis, necessitating quick medical intervention to protect vision and the eye's structure.
- A study involving three patients showed that applying a fresh-tissue corneolimbal graft during emergency surgery effectively sealed the perforation and helped heal the cornea without complications.
- The findings suggest that fresh-tissue corneolimbal grafts are a viable treatment option for severe corneal issues related to rheumatoid arthritis.
Article Synopsis
- Myopic individuals, especially those with severe myopia, face higher risks of serious eye conditions like cataracts and retinal detachment, often leading to visual impairment.
- The study investigates the effect of scleral crosslinking (using riboflavin and UV-A radiation) on preventing axial myopia in a rabbit model by measuring eye length changes.
- Results show that this technique effectively reduces induced axial elongation in the rabbits, suggesting potential benefits for treating myopia-related issues.
Article Synopsis
- The study investigated the impact of scleral cross-linking using riboflavin and UV-A light on axial myopia in 22 young rabbits.
- The experimental group underwent scleral cross-linking, while the control group did not, with measurements of eye length taken after 55 days.
- Results showed a significant difference in axial elongation, with the experimental group experiencing less growth in eye length compared to the control group, indicating the effectiveness of the treatment.
Article Synopsis
- The study compared outcomes of mushroom femtosecond laser-enabled keratoplasty (M-FLEK) with traditional penetrating keratoplasty (PKP) in keratoconus patients, finding M-FLEK resulted in less postoperative astigmatism and better preservation of endothelial cells.
- Conducted over two years, it analyzed data from 26 M-FLEK and 33 PKP eyes on visual acuity, endothelial cell counts, and complications.
- Results showed similar best-corrected visual acuity between groups, but M-FLEK had lower mean manifest cylinder values and less endothelial cell loss, indicating it may be a safer option.
Article Synopsis
- The study aimed to evaluate the effectiveness of recombinant tissue plasminogen activator (r-tPA) for patients experiencing severe fibrin reactions in the anterior chamber following cataract surgery.
- Conducted at a university medical center, it involved 40 patients who weren't responding to traditional steroid treatments and received r-tPA injections after surgery.
- Results showed an 80% complete clearance rate of the fibrin reaction within one day and a 95% resolution after one month, indicating that r-tPA is a safe and promising treatment option.
Article Synopsis
- The study aimed to assess the protective effect of Biolon (a 1% sodium-hyaluronate solution) on the corneal endothelium during the harvesting of donor corneas.
- It involved a randomized, double-blind trial with 120 corneas from 60 donors, comparing endothelial cell density (ECD) between corneas harvested with and without the injection of an ophthalmic viscosurgical device (OVD).
- Results indicated that the OVD group had a higher ECD (2839 cells/mm²) compared to the control group (2748 cells/mm²), suggesting that OVD may help prevent mechanical damage, although further research is necessary before making it a standard practice.
Corneal graft failure following Nd:YAG laser membranotomy for inadvertent retained descemet's membrane after penetrating keratoplasty.
Ophthalmic Surg Lasers Imaging
September 2012
Retained Descemet's membrane (DM) following penetrating keratoplasty (PKP) is a rare finding that may reduce visual acuity following opacification or endanger the graft endothelium. The association between Nd:YAG laser membranotomy and corneal graft failure is reported. Five of 1,350 patients (0.
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- The study investigates the effects of performing simultaneous photorefractive keratectomy (PRK) and corneal collagen crosslinking (CXL) on patients with keratoconus who had previously undergone intrastromal corneal ring segment (ICRS) implantation.
- Conducted at Enaim Laser Center in Jerusalem, the research assessed various eye health parameters over 12 months, including uncorrected and corrected distance visual acuities, and keratometry values.
- Results showed significant improvements in visual acuity and corneal curvature post-treatment, indicating the safety and effectiveness of this combined procedure in enhancing the vision of patients with moderate keratoconus.
Purpose: To investigate the effect of corneal collagen cross-linking (CCL) on tonopen measurements of intraocular pressure (IOP).
Methods: CCL with 0.1% riboflavin solution and 30 min of ultraviolet A radiation was performed on the right eye of 15 New Zealand albino adult rabbits (1.
Article Synopsis
- The study examined the effectiveness of phototherapeutic keratectomy (PTK) in myopic patients experiencing spontaneous recurrent corneal erosions (RCE) after IntraLASIK surgery.
- The patients had initially suffered erosions 3-6 months post-surgery, which were treated but recurred until PTK was performed, leading to complete healing within 8-10 days.
- Post-treatment, the patients experienced no loss of best-corrected visual acuity, although a slight haze remained, and there were no recurrences of corneal erosion during the follow-up period.
Endophthalmitis and wound dehiscence following late removal of penetrating keratoplasty sutures.
Ophthalmic Surg Lasers Imaging
August 2011
Article Synopsis
- A study reviewed 207 cases of penetrating keratoplasty (PK) at Beilinson Hospital, focusing on patient characteristics and outcomes of wound dehiscence after late suture removal.
- Out of the 207 cases, 4 (1.93%) developed severe complications like spontaneous wound dehiscence and endophthalmitis, with a notable incidence of bacterium infections identified as Streptococcus and Staphylococcus.
- The study highlights that while these complications are rare, they can lead to severe outcomes, including loss of vision, emphasizing the need for careful monitoring and consideration of alternative corneal transplant methods.
Purpose: To assess the effects of NDM from cranberries on Staphylococcus epidermidis biofilm formed on soft contact lenses.
Methods: Soft contact lenses were incubated in Tryptic Soy Broth (TSB) together with S. epidermidis (ATCC35984/RP62A) and various concentrations of NDM, and inspected by scanning electron and confocal microscopy.
Multiple Conjunctival Papillomas of Eyelid Margins in Pemphigus vulgaris.
Case Rep Ophthalmol Med
August 2012
Article Synopsis
- - Ocular symptoms of pemphigus vulgaris can vary from mild conjunctivitis to more severe conditions like conjunctival blisters and erosions at the edges of the eyelids.
- - The report discusses two rare cases of pemphigus vulgaris where patients exhibited multiple papillomatous lesions on their eyelid margins.
- - These cases highlight a less common manifestation of PV, emphasizing the need for awareness of ocular symptoms in this disease.
Purpose: To report a case of corneal subepithelial infiltrates appearing after intravitreous bevacizumab injections.
Methods: A review of the patient's history and clinical examination findings in a patient who had epidemic keratoconjunctivitis more then 20 years before treatment with bevacizumab for age-related macular degeneration.
Results: After the third and fourth bevacizumab injections, the patient presented with unilateral corneal subepithelial infiltrates.
Article Synopsis
- The study aimed to assess how effective mitomycin C (MMC) is in promoting epithelial healing after photorefractive keratectomy (PRK) in myopic patients.
- A total of 1,520 eyes from 760 myopic patients had PRK with MMC applied post-surgery, while comparing results with a previous group of 500 eyes treated without MMC.
- Results showed that 3.5% of MMC-treated eyes experienced delayed healing compared to 0.8% in the non-MMC group, but no final haze was observed in the MMC group, demonstrating a significant difference in outcomes.
Article Synopsis
- This study aimed to assess how well bevacizumab (Avastin) reduces corneal neovascularization in mice and compares different injection methods (intraocular vs. subconjunctival).
- Neovascularization was induced in 125 mice, who then received bevacizumab via different injection routes, with results measured through digital imaging, immunohistochemistry, and VEGF level analysis.
- Results showed that bevacizumab treatment reduced neovascularization, with intraocular injections being the most effective, while subconjunctival injections had the fastest initial response.
Article Synopsis
- The study investigates the link between the viscoelastic material Multivisc BD and the occurrence of toxic anterior segment syndrome (TASS) after phakic intraocular lens (IOL) surgery.
- Two patients experienced severe inflammation in the anterior chamber after receiving an IOL, which was treated with antibiotics and steroids, leading to a complete resolution of inflammation and improved vision.
- The findings suggest that Multivisc BD may be contaminated by bacterial toxins, highlighting the need for refractive surgeons to be cautious about using new viscoelastic materials due to potential rare complications like TASS.
Article Synopsis
- The study investigated how intravitreal injection of bevacizumab (Avastin) affects the growth and structure of young rabbits' eyes.
- Twelve rabbits received the treatment in one eye, while six additional rabbits acted as control subjects without any injection.
- Results showed no significant differences in eye growth or structure between treated and untreated eyes, suggesting that bevacizumab does not negatively impact the development of young rabbit eyes.
Fresh-tissue corneolimbal covering graft for large corneal perforation following childhood trachoma.
Ophthalmic Surg Lasers Imaging
June 2009
Background And Objective: When corneal perforation develops in patients with severe ocular surface disease and limbal stem cell deficiency following childhood trachoma infection, penetrating keratoplasty is doomed to fail. To overcome this problem, the use of a fresh-tissue corneolimbal covering graft is described.
Patients And Methods: Retrospective interventional case series of four patients who presented to a tertiary center from 2003 to 2005 with a large corneal perforation due to ocular surface disease.
Purpose: This is a case study of Fusarium keratitis progressing to endophthatmitis that was successfully treated with a tiposomal formulation of amphotericin B (AmBisome] and local natamycin 5%.
Methods: A 41-year-old man presented with a clinical picture of endophthalmitis following deep Fusarium solani keratitis. Treatment with natamycin 5% drops and intravenous amphotericin B 150 mg per day caused renal failure and did not alleviate the endophthalmitis.
Purpose: To evaluate the clinical outcome of wavefront-guided LASIK in patients with low to high myopia.
Methods: The study included 316 eyes of 158 patients; 172 eyes with low to moderate myopia (< or = 6.00 diopters [D]) and 144 eyes with high myopia (> or = 6.
Refractive eye surgery in treating functional amblyopia in children.
Binocul Vis Strabismus Q
December 2006
Article Synopsis
- The study investigates the use of excimer laser refractive surgery in children with severe vision problems, particularly those with amblyopia stemming from high anisometropia, high astigmatism, and high myopia, including some with developmental delays.
- A review of 11 children who had previously unsuccessful non-surgical treatments showed that the surgery effectively reduced refractive errors and improved vision and daily functioning.
- The findings suggest that refractive surgery is a safe and effective option for improving visual acuity in children with specific vision issues that aren’t responsive to standard treatments.
Article Synopsis
- The study aimed to assess the safety and effectiveness of wavefront-supported photorefractive keratectomy (PRK) for treating myopia and myopic astigmatism in patients with potential keratoconus.
- Forty eyes from 20 patients were treated, showing significant improvement in mean visual acuity post-surgery and a high rate of achieving the intended refractive outcomes.
- The results suggest that wavefront-supported PRK can effectively manage myopia and astigmatism in patients with thin, irregular corneas, but further long-term studies are necessary to confirm its safety.
Laser in situ keratomileusis in myopic patients with congenital nystagmus.
J Cataract Refract Surg
March 2006
Purpose: To evaluate the results of laser in situ keratomileusis (LASIK) and IntraLASIK in the treatment of myopic patients with nystagmus.
Methods: Eight patients with congenital nystagmus (16 eyes), aged 23 to 49 years, had LASIK surgery. Corneal flaps were created using the Bausch & Lomb Hansatome microkeratome or the IntraLase femtosecond laser.