A novel lectin called AcrL was isolated from the marine sponge Aiolochroia crassa, which specifically binds to glycans with sialic acid and shows a typical galectin structure with carbohydrate-binding sites.
AcrL demonstrated strong antibacterial effects by inhibiting biofilm formation in bacteria such as Staphylococcus aureus and Escherichia coli, with varying concentrations required for effectiveness.
The lectin also enhances the efficacy of antibiotics and damages bacterial membranes, suggesting its potential as a new antibacterial agent in the fight against infections.