A phase I study of temsirolimus in combination with metformin in patients with advanced or recurrent endometrial cancer.

Introduction: Molecular alterations in the PI3K/AKT and Ras/Raf/MEK/ERK pathways are frequently observed in patients with endometrial cancers. However, mTOR inhibitors, such as temsirolimus, have modest clinical benefits. In addition to inducing metabolic changes in cells, metformin activates AMPK, which in turn inhibits the mTOR pathway.

PREVALENCE OF COGNITIVE IMPAIRMENT AND ITS ASSOCIATED FACTORS AMONG TYPE 2DIABETIC PATIENTS: FINDING FROM A CROSS SECTIONAL STUDY IN IRAQ.

Diabetes mellitus is a metabolic condition characterized by chronic hyperglycemia and disturbance in body metabolic state. It is estimated that nearly half of patients with diabetes will suffer from cognitive impairment and impairment in the performance of daily functions. The aim was to determine the prevalence of cognitive impairment and its predictors among diabetics.