Isolated Inguinal Lymph Node Metastasis from Colon Cancer: A Case Report.

Lymphatic spread of colon cancer usually occurs via mesenteric vessels (superior and inferior mesenteric vessels), but inguinal lymph node (LN) metastasis from colon cancer is extremely rare with only few reported cases in the literature. A case of a 35-year-old female patient with a history of sigmoid cancer underwent sigmoidectomy and left salpingo-oopherectomy in 2016 and received adjuvant chemotherapy then presented in 2023 with metastatic left inguinal LNs and underwent left inguinal LN dissection. We reported a rare case of isolated metachronous inguinal lymph node metastasis from colon cancer with a round ligament route of spread as the hypothesized mechanism.

Prognostic Outcome of Mesenchymal Transition Biomarkers in Correlation with EGFR Expression in Epithelial Ovarian Carcinoma Patients.

Background: CD44 is an epithelial-mesenchymal transition (EMT) surface receptor that regulates the interactivity between the cells and the extracellular matrix, thereby promoting cell migration. The epidermal growth factor receptor (EGFR) family is a trans-membrane kinase-related protein. It regulates cell adhesion proteins, which may promote cell proliferation and invasiveness.