Publications by authors named "Isra Sadiya"
Article Synopsis
- RGS proteins, like RGS2, inactivate Gα subunits and regulate G protein-coupled signaling networks, with RGS2 exclusively interacting with Gα subunits.
- Research reveals that three specific residues in RGS2 influence its unique interaction mode with Gα, primarily via the Gα GTPase domain.
- The study identifies key residues in the Gα helical domain as crucial for RGS2 specificity, offering insights into G protein interactions that could aid in designing new drugs and understanding signaling pathways.
Article Synopsis
- * RGS proteins, particularly from the R12 subfamily, show lower activity in regulating G proteins compared to the R4 subfamily, where we've identified key "disruptor residues" affecting this activity.
- * By engineering RGS proteins with and without these disruptor residues, we found that altering these positions can significantly change the activity levels toward Gα proteins, indicating they play a crucial role in regulating G protein signaling.
