Publications by authors named "Isoda K"

Background: Platelet-rich plasma (PRP) is a promising treatment for knee osteoarthritis (OA). However, exercise therapy and activities of daily living (ADL) guidance are recommended as core treatments in the Osteoarthritis Research Society International (OARSI) guidelines. However, the effects of PRP combined with exercise therapy are not fully understood.

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We report a liquid material based on an L-valine-appended pyromellitic diimide framework. This liquid adopts a room-temperature liquid with at -50 °C and can dissolve naphthalene derivatives to show various photoluminescent colors. Furthermore, the on/off photoluminescence of these solutions can be controlled by heating.

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We report the facile synthesis of asymmetric perylene diimides (asym-PDIs) using readily available reagents, demonstrating their distinct photoluminescent properties. In CHCl, asym-PDIs exhibit higher solubility compared to traditional perylene dyes, of which solubilities can be varied by substituent selections. Among them, UV-vis absorption spectra of CPE in CHCl solution displayed no aggregate peaks in the ground state, maintaining high photoluminescent quantum yields.

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Background: Since the complication of diabetes mellitus (DM) is a risk for adverse cardiovascular outcomes in patients with coronary artery disease (CAD), appropriate risk estimation is needed in diabetic patients following percutaneous coronary intervention (PCI). However, there is no useful biomarker to predict outcomes in this population. Although stromal cell derived factor-1α (SDF-1α), a circulating chemokine, was shown to have cardioprotective roles, the prognostic impact of SDF-1α in diabetic patients with CAD is yet to be fully elucidated.

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Nanoparticles are used in a variety of fields; for example, titanium oxide nanoparticles are used in paints, food additives, cosmetics, and sunscreen materials. Although the use of titanium oxide nanoparticles is regulated, their safety has not been established. Furthermore, the interaction between titanium oxide nanoparticles and various chemical substances and pharmaceuticals is unknown.

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Unlabelled: A 78-year-old woman with hypertension was admitted to our hospital with palpitation and chest discomfort. She had been nervous since she learned about a severe earthquake on the news. An electrocardiogram showed ST-segment elevation in leads I, aVL, and V2-6.

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Subungual abscesses are rare, and information about them through imaging findings is lacking. Carbon dioxide laser drainage and antibiotics are effective treatment strategies for subungual abscesses. We report a case of a 47-year-old male healthcare worker with a subungual abscess that improved after manual drainage alone.

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Background: According to 2023 ESC Guideline, conservative medical management is generally recommended for the treatment of spontaneous coronary artery dissection (SCAD) except for patients with signs of ongoing myocardial ischemia. However, in some cases, invasive treatment (coronary artery bypass graft surgery or percutaneous coronary intervention (PCI)) is performed because of the progression of aneurysm in SCAD. Although there is no established strategy for the management of coronary aneurysm in SCAD, we report a case of successful healing of aneurysmal false lumen (AFL) using a second-generation drug-eluting stent (DES) in SCAD.

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Background: Interstitial lung disease (ILD) related to rheumatoid arthritis (RA) is among the leading causes of death and an essential prognostic factor. There is only limited evidence for the safety of anti-rheumatic drugs for patients with RA-ILD. The aim of this study is to investigate the safety and efficacy of Janus kinase inhibitors (JAKis) by comparing it with abatacept (ABT) in patients with RA-ILD.

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A 79-year-old male with effort angina was admitted to receive optical coherence tomography (OCT)-guided percutaneous coronary intervention for restenosis of an everolimus-eluting stent implanted to the left anterior descending artery (LAD) eight years ago.

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Pathogenic variants in the HIBCH gene cause HIBCH deficiency, leading to mitochondrial disorders associated with valine metabolism. Patients typically present with symptoms such as developmental regression/delay, encephalopathy, hypotonia and dystonia. Brain magnetic resonance imaging (MRI) shows bilateral lesions in the basal ganglia with/without brainstem involvement.

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Reductive cyclization of enynes and diynes by using H gas as a reductant was realized, and the corresponding cyclized products were obtained in good yields without olefin isomerization and over-reduction of the products. By an experiment using D instead of H, it was confirmed that H unambiguously operates as a reductant in this reaction. The protocol of the reaction is very economical and user-friendly, using air- and moisture-stable CoBr·6HO and 1 atm of pressure of H.

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Aim: Although it is known that advanced age alters skeletal muscle lipid metabolism, the role(s) of polyunsaturated fatty acid-derived metabolites (mostly eicosanoids and docosanoids) in sarcopenia are not clear. We therefore examined the changes in the metabolites of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid in the sarcopenic muscle of aged mice.

Methods: We used 6- and 24-month-old male C57BL/6J mice as healthy and sarcopenic muscle models, respectively.

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Article Synopsis
  • The study aims to assess the safety and effectiveness of daprodustat, a HIF-PH inhibitor, in treating renal anaemia in patients with heart failure (HF), filling a gap in existing research.
  • It involves a pilot trial with 50 patients who have both HF and chronic kidney disease, randomized to receive either daprodustat or a control treatment, while monitoring their haemoglobin levels and cardiac function.
  • The findings could provide crucial insights into new treatment options for anaemic patients with HF and chronic kidney disease, where current treatments are limited.
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  • Previous studies indicated that higher levels of apolipoprotein A1 (ApoA1) and high-density lipoprotein cholesterol (HDL-C) are linked to lower cardiovascular mortality after percutaneous coronary intervention (PCI), but the relationship between ApoA1 and cancer mortality in this context has not been thoroughly explored.
  • This research used a retrospective analysis of a database from a single center, involving 3,835 patients who underwent PCI between 2000 and 2018, focusing on the impact of ApoA1 levels on the mortality rates from various cancers.
  • Results revealed that patients in the lowest ApoA1 group had significantly higher rates of total, gastrointestinal, and lung cancer mortality compared to those in the highest group, while
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Objectives: This study investigated postpartum bone mineral density (BMD) in patients with systemic lupus erythematosus (SLE) receiving long-term glucocorticoid (GC) therapy, assessed risk factors for decreased postpartum BMD, and evaluated change of BMD after postpartum initiation or restarting of osteoporosis drugs.

Methods: We retrospectively examined 30 SLE patients who gave birth and 31 non-pregnant SLE patients. In the postpartum SLE patients, BMD was measured after delivery and 1 year later.

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Article Synopsis
  • Dipeptidyl-peptidase-4 inhibitors (DPP4i) are popular antidiabetic medications known for their safety and low risk of causing low blood sugar, although their overall cardiovascular benefits have been debated.
  • This study focused on Japanese diabetic patients with coronary artery disease who underwent percutaneous coronary intervention, finding that DPP4i usage was significantly linked to lower risks of cardiovascular death and major adverse cardiac events, especially in patients with a BMI of 25 or less.
  • Additionally, the study highlighted that increased activity of insulin-like growth factor-1 (IGF-1) was associated with better outcomes in patients taking DPP4i, indicating a potential mechanism behind their beneficial effects.
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Objective: To investigate the influence of nutritional status on severe infection complications in patients with rheumatoid arthritis (RA).

Methods: This retrospective cohort study on 2108 patients with RA evaluated the prognostic nutritional index (PNI) as an index of nutritional status. Patients were classified into the high or low PNI group according to the cutoff PNI value (45.

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Background: Patients with end-stage renal disease (ESRD) on chronic hemodialysis who are complicated by coronary artery disease (CAD) are at very high risk of cardiovascular (CV) events and mortality. However, the prognostic benefit of statins, which is firmly established in the general population, is still under debate in this particular population.

Methods: As a part of a prospective single-center percutaneous coronary intervention (PCI) registry database, this study included consecutive patients on chronic hemodialysis who underwent PCI for the first time between 2000 and 2016 ( = 201).

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