Publications by authors named "Iso H"
Aims: Long-term exposure to fine particulate matter (PM) is causally associated with mortality and cardiovascular disease. However, in terms of cardiovascular cause-specific outcomes, there are fewer studies about stroke than about coronary heart disease, particularly in Asia. Furthermore, there remains uncertainty regarding the PM-respiratory disease association.
View Article and Find Full Text PDFBackground: Reducing premature noncommunicable disease (NCD) mortality is a global challenge. Sodium is thought to increase risk of NCDs via an effect of salt per se or high-salt foods on hypertension-induced cardiovascular disease (CVD) and gastrointestinal cancer. Further, relative risk of CVD is reportedly more closely associated with sodium-to-potassium ratio than that with sodium alone.
View Article and Find Full Text PDF: COVID-19 patients develop various clinical symptoms, including malnutrition. However, the risk factors for long-term nutritional disorders remain unclear. Identifying these factors is crucial for preventing nutritional disorders by initiating early nutritional interventions.
View Article and Find Full Text PDFObjectives: The effect of the COVID-19 booster vaccination and the long-term consequences concerning preventing post-COVID-19 condition (PCC) remains unclear. We aimed to investigate the association of COVID-19 booster vaccination dose and vaccination timing before infection with the risk of PCC during the Omicron variant-dominant wave.
Methods: This population-based study included patients confirmed with COVID-19 (extracted from the Health Center Real-time Information-sharing System) aged 20-69 years, who were infected between 1 July and 31 August 2022.
Article Synopsis
- This study examines how flat rate pricing for unlimited alcohol at restaurants and bars affects drinking behaviors during the COVID-19 pandemic, focusing on problematic consumption patterns as measured by the AUDIT.
- Data from a large survey of nearly 20,000 current drinkers showed that those using flat rate pricing reported significantly higher rates of problem drinking and binge drinking compared to non-users.
- The findings suggest that flat rate pricing is linked to increased hazardous drinking and probable alcohol use disorders, indicating a potential risk factor for heavy alcohol consumption.
Background: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. This study aims to elucidate the relationships between medical history of different CL/P types and infectious diseases to serve as a reference for the comprehensive care of patients with CL/P.
View Article and Find Full Text PDFArticle Synopsis
- This study explored how using cigarettes and heated tobacco products (HTPs) affects breastfeeding duration among women before, during, and after pregnancy in Japan.
- An internet-based survey analyzed data from 4,005 women who gave birth between January 2019 and February 2021.
- The results showed that women who used cigarettes or both cigarettes and HTPs were more likely to stop breastfeeding early, while those who only used HTPs did not have the same risk.
Article Synopsis
- This study compares in-hospital and 5-year mortality rates in patients with STEMI and NSTE-ACS who underwent coronary artery angiography (CAG) and percutaneous coronary intervention (PCI) versus those who did not.
- Propensity score matching was used to create equivalent groups based on age, sex, and health conditions, utilizing national health data from Thailand.
- Results indicated significantly lower mortality rates for patients who received CAG and PCI, with in-hospital mortality at 30.1% for STEMI and 34.7% for NSTE-ACS, suggesting the importance of these interventions in improving patient outcomes.
Article Synopsis
- A study followed 40,272 men and 54,902 women in Japan for 19.3 years to investigate how sleep duration affects death from chronic kidney disease.
- Participants were grouped based on sleep duration (less than 6 hours to more than 9 hours) and analyzed using Cox proportional hazard models.
- Results indicated that sleeping 8-9 hours or more than 9 hours per day significantly increased the risk of chronic kidney disease mortality, particularly in individuals under 65 years old.
Article Synopsis
- The COVID-19 pandemic significantly increased the rate of home deaths among cancer patients in Japan, rising from 11.6% pre-pandemic to 20.8% during the pandemic.
- Analysis of vital statistics revealed that younger cancer patients were more likely to die at home during the pandemic, contrasting with older patients who had a higher proportion of home deaths before.
- The findings highlight the need for improved resources for home and hospital end-of-life care to support patients' preferences during health crises.
Introduction: Nutritional therapy is an important component of intensive care. We investigated the associations of nutritional therapy in the acute phase of severe COVID-19 with the long-term outcomes of post-intensive care syndrome (PICS) and post-COVID-19 conditions.
Methods: A questionnaire on the health status after COVID-19 was sent to patients 1 year after infection and PICS was evaluated.
Article Synopsis
- Twins show a delay in early psychomotor development compared to singletons, with this lag persisting into early childhood.
- The study compared the developmental outcomes of singletons, monochorionic (MC) twins, and dichorionic (DC) twins using data from the Japan Environment and Children's Study (JECS).
- The delays in twins' development are mainly linked to lower birth weights and earlier gestation, with only minor differences observed between MC and DC twins.
Aims: Few studies have investigated the impact of sleep duration at night and daytime napping on mortality from aortic disease. In this study, we examined the associations of sleep duration at night with daytime napping and mortality from aortic disease.
Methods: We followed 67,269 participants (26,826 men and 40,443 women, aged 40-79 years) who were not night shift workers and had no history of stroke, heart disease, or cancer.
Background: The benefit of adjuvant therapy remains controversial in completely resected (R0) stage IB non-small cell lung cancer (NCLSC) patients. In this study, we aimed to explore potential prognostic factors in stage IB NSCLC patients.
Methods: This study included 215 patients with R0 stage IB lung adenocarcinoma (LUAD) (tumor size: 3-4 cm).
Article Synopsis
- The study focused on identifying risk factors for intracerebral hemorrhage (bleeding within the brain) by examining different bleeding sites and their specific associations with various health factors.
- It involved a large population of 34,137 Japanese adults followed over 20 years, analyzing factors like age, sex, blood pressure, and lifestyle choices.
- Key findings indicated that hypertension increased the overall risk, low cholesterol was linked to specific lobar hemorrhages, and heavy drinking and obesity were related to putamen hemorrhage, highlighting the need for targeted prevention strategies.
Article Synopsis
- The study explored the impact of cardiovascular and lifestyle risk factors on mortality from chronic kidney disease in the Japanese population over an 18.8-year period.
- It included a large sample of nearly 106,000 adults aged 40-79, analyzing data using Cox proportional hazard models.
- Key findings indicated that high body mass index, hypertension, diabetes, smoking, and low exercise were linked to increased mortality risk, while moderate drinking and regular exercise were associated with lower risk.
Article Synopsis
- Vaccination against COVID-19 is linked to a lower risk of developing post-coronavirus disease condition (PCC) among infected individuals during Omicron-dominant waves in Japan.
- A study analyzed data from 4,185 COVID-19 cases and 3,382 healthy controls, using surveys to evaluate long-term symptoms and risk factors.
- Results indicated that while 15% of infected individuals experienced PCC, vaccination significantly reduced the risk, especially during earlier Alpha and Delta waves compared to the Omicron wave, with female sex and pre-existing conditions also increasing the risk of PCC.
Article Synopsis
- Adequate nighttime sleep duration is linked to better linear growth in children, particularly from ages 1.5 to 3 years.
- A study involving over 52,000 children in Japan found that sleep duration significantly predicted tall stature at age 3 when considering various factors like mother's height and household income.
- The findings suggest that nighttime sleep is crucial for growth, while total sleep duration (including naps) does not show a similar association.
Background: Having positive psychological well-being has been associated with serum high-density lipoprotein cholesterol (HDLC), but no longitudinal study to date has examined the association between Ikigai and serum HDLC. Therefore, we examined the association between Ikigai and change in serum HDLC over time using a cohort dataset spanning 2010-2018.
Methods: The study included 471 men and 776 women aged 40-74 years who underwent a cardiovascular examination in 2010 and were asked their levels of Ikigai.
Article Synopsis
- - The study examined how socioeconomic status (SES) affects cardiovascular health (CVH) differently for men and women, using data from over 31,000 participants in South Korea between 2007 and 2017.
- - Four SES classes were identified, with lower SES linked to significantly lower chances of achieving ideal CVH, particularly for women (OR: 0.55) compared to men, where the results were less clear (OR: 0.83).
- - The findings suggest that targeted interventions to address SES disparities and empower low-income groups, especially women, are essential for improving cardiovascular health outcomes.
Aims/introduction: A recent US Food and Drug Administration report highlighted concerns over nitrosamine (7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4] triazolo-[4,3-a]pyrazine [NTTP]) impurities in sitagliptin, prompting investigations into its safety profile. The present study aimed to determine if the use of NTTP-contaminated sitagliptin, in comparison with other dipeptidyl peptidase-4 (DPP-4) inhibitors, is associated with an increased cancer risk.
Materials And Methods: This retrospective cohort study secondarily used the National Database of Health Insurance Claims and Specific Health Checkups of Japan, encompassing data on >120 million individuals.
Introduction: Global health hazards caused by air pollution, such as chronic kidney disease (CKD), have been gaining attention; however, air pollution-associated CKD has not been explored in Japan.
Methods: We examined 77,770 men and women with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m in the Ibaraki Prefecture who participated in annual community-based health checkups from 1993 at 40-75 years old and were followed up through December 2020.
Article Synopsis
- Numerous antibody biomarkers exist for cancer and atherosclerosis-related diseases, highlighting the connections between conditions like acute ischemic stroke, cardiovascular disease, and diabetes mellitus.
- The study identifies KIAA0513 as a potential common biomarker linked to these diseases, showing higher serum antibody levels in patients compared to healthy individuals.
- The research suggests that serum anti-KIAA0513 antibody levels could effectively diagnose various conditions, indicating shared arterial changes associated with both atherosclerosis and cancer.
Article Synopsis
- - The study aimed to investigate how the gestational age at birth affects the likelihood of growth failure and respiratory issues (like asthma and wheezing) in children by age 3.
- - Researchers analyzed data from over 86,000 infants born at 32-41 weeks gestation and used logistic regression to assess risks, factoring in various socioeconomic and perinatal influences.
- - Findings indicated that infants born moderately preterm, late preterm, and early term had significantly higher chances of experiencing growth failure and respiratory symptoms at age 3 compared to those born full-term, showing a pattern where the earlier the birth, the higher the risk.