Development and in vitro cytotoxic evaluation of parenteral docetaxel lipid nanoemulsions for application in cancer treatment.

The aim of the present study was to develop stable lipid nanoemulsions (LNEs) for delivery of docetaxel for treatment of cancer. The LNEs of docetaxel were prepared by using olive oil and egg lecithin by hot homogenization followed by ultrasonication. The influence of formulation variables such as change in proportion of charge inducers, that is, oleic acid (negative) and stearyl amine (positive), was studied.