Mild Congenital Hyperinsulinism Caused by Mutation in Human Gene.

Congenital hyperinsulinism (CHI) is a rare hereditary disease characterized by the development of hypoglycemia in both infants and adult patients. CHI may be induced by activating mutations in the () gene, which encodes the human glucokinase enzyme. This form of the disease is characterized by considerable phenotypic heterogeneity and may vary in severity of its course.

COMPARATIVE ANALYSIS OF HEPATOPROTECTORS IN WISTAR RATS WITH EXPERIMENTALLY INDUCED METABOLICALLY ASSOCIATED FATTY LIVER DISEASE.

The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease (MAFLD) and type 2 diabetes mellitus (T2DM). Because of the similarity in pathobiology shared between T2DM and MAFLD, both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual diseases. In fact, awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and diabetologists.

[Laser analyzer as an objective method for evaluating walking parameters in patients with post-stroke disorders].

Objective: To estimate the informativity, sensitivity and specificity of the method of assessing gait function in patients with ataxia and post-stroke hemiparesis using the LA-1 «Laser Analyzer of Kinematic Gait Parameters».

Materials And Methods: Main tempo-rhythm and spatial gait parameters were assessed in groups of healthy people of young (=30) and middle (=30) age. At the second stage, the gait parameters of healthy people were compared with those of patients with ataxia due to vertebrobasilar stroke (=30) and with post-stroke hemiparesis (=30).

[Dynamics of cognitive impairments during L-dopa therapy in Parkinson's disease].

Objective: To assess the dynamics of cognitive impairments (CI) in patients with Parkinson's disease (PD) during L-dopa therapy.

Material And Methods: The randomized clinical study included 41 patients with a refined diagnosis of PD 2.5-3.

[The new approach in the treatment of walking disorders in Parkinson's disease].

Aim: To evaluate the efficacy of a proprietary method based on stimulation of the hindfoot when lifting the foot from the surface of the support and bringing it forward in the treatment of walking disorders in patients with Parkinson's disease (PD).

Material And Methods: The study included 19 patients with walking disorders, akinetic-rigid and mixed form of PD. The stage of the disease on the Hoehn-Yahr scale at the time of the study was 2.

[Assessment of walking function in neurological practice].

An accurate diagnosis of the existing defect of motor function in patients with neurological pathology is necessary for the optimal formulation of the rehabilitation program, selection of drug therapy and evaluation of the effectiveness of treatment. In current clinical practice, clinical scales such as the Dynamic Gait Index, the Rivermid Mobility Index, the Hauser Walk Index, the Stand Up and Go Test, the MDS-UPDRS III are used most often to assess walking function. Evaluation of walking function using valid scales is very accessible, however, it has such a disadvantage as subjectivity.

[The efficiency of psychological educational programs under depressive disorders].

The psychological educational programs make possible to increase level of awareness of depression in patients with depressive conditions and to enhance coping of patients with symptoms of disease. In scientific publications, the experience of application of both full-time group and individual and nonresident psychological educational programs is exposed The result of implementation of these programs consists in decreasing of expression depression symptoms, increasing of number of remissions, increasing of commitment to pharmaceutical treatment and decreasing of rate of refusals of treatment and increasing of rate of seeking of professional medical care in case of exacerbation of disease. The psychological educational programs ameliorate socialfunctioning, work capacity, quality of life and life satisfaction in patients.

[Comparative study of superoxide dismutase and glutathione peroxidase activity in embryos and skeletal muscles of adult fish].

The activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase in loach and sturgeon embryogenesis as well as in red and white skeletal muscles of loach was studied. The specific activity of cytoplasmic and mitochondrial forms of superoxide dismutase in developing sturgeon embryos was higher than in loach embryos, which may be due to oxygen conditions under which these species develop in nature. A similar dependence was also observed for the activity of glutathione peroxidase in embryos of these fish species.

[Prevalence of carbohydrate metabolism disorders in free-living females of capable age in the city of Baku].

Aim: The study of prevalence of carbohydrate metabolism disorders (CHMD) in females.

Materials And Methods: A representative sample of 20-59-year-old female population of the city of Baku was examined using age-specific standardized index, WHO tests and criteria.

Results: CHMD occurred rather frequently.

[Prognosis of the probability of development of ischemic heart disease with regard to family anamnesis in a Baku male population of 20-54 years of age].

The analysis of the results obtained from a genetic population survey among an unorganized Baku male population aged 20-54 years provided quantitative assessments of a set of informative signs to reveal the factors predisposing to coronary heart disease. Predictive indicators of empirical and theoretical risk of the disease were constructed on the basis of the signs selected.