[Effect of different levels of thyroid hormones on the fatty acid composition of lipids from rat liver mitochondria].

The abundance or deficiency of thyroid hormones in rat organism influence the unsaturation and desaturation indices of total lipid fatty acids and phospholipids in liver mitochondria. The most conspicuous changes were observed in the fatty acid composition of the phospholipid fraction. The changes in the structure and function of rat liver mitochondria are considered to be due to alterations in the fatty acid composition of mitochondrial phospholipids.

[Oxidation of palmityl carnitine in mitochondria of rat heart and liver tissue under conditions of thyroid pathology].

Effects were studied of various doses of thyroid hormones and thyroidectomy on oxidation of palmityl carnitine and caprylate in heart and liver mitochondria as well as on the rate of oxidation of succinate and alpha-ketoglutarate in brain mitochondria. Depending on the dose of the thyroid hormone the rate of fatty acid oxidation varied. The stimulatory doses of thyroxin and thyroidectomy altered (increased or decreased) the rate of electrone transport in the respiratory chain but the respiratory control and the ADP/O ratio were only slightly changed.