Publications by authors named "Ismail Mohamed Elshaffei"
Article Synopsis
- The study investigates the neurotoxic effects of methotrexate (MTX) in rats, linked to microglial activation, and how the flavonoid apigenin (Api) may counteract these effects.
- Experimental groups included: a normal control, an Api-only group, an MTX-only group, and an Api co-treatment group subjected to MTX, examining changes in neuroinflammation, oxidative stress, and cognitive functions.
- Findings suggest that Api reduces MTX-induced neurotoxicity by targeting the miR-15a/ROCK-1/ERK1/2/CREB/BDNF pathway, leading to less inflammation and improved cognitive performance.
Dexmedetomidine Attenuates Methotrexate-Induced Neurotoxicity and Memory Deficits in Rats through Improving Hippocampal Neurogenesis: The Role of miR-15a/ROCK-1/ERK1/2/CREB/BDNF Pathway Modulation.
Mohamed Taha Omar Mohsen Eldemerdash Ismail Mohamed Elshaffei Einas Mohamed Yousef Mahmoud A Senousy
Int J Mol Sci
January 2023
Methotrexate (MTX) is a widely used neurotoxic drug with broad antineoplastic and immunosuppressant spectra. However, the exact molecular mechanisms by which MTX inhibits hippocampal neurogenesis are yet unclear. Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, has recently shown neuroprotective effects; however, its full mechanism is unexplored.
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