A Promising Resveratrol Analogue Suppresses CSCs in Non-Small-Cell Lung Cancer via Inhibition of the ErbB2 Signaling Pathway.

The ErbB2 signaling pathway plays a crucial role in cancer stem cells (CSCs), governing cancer aggressiveness and proliferation. Targeting ErbB2 holds promise for advancing cancer therapeutics. Resveratrol (RES) and its derivatives have been noted for their ability to target proteins that are involved in CSCs.

Rational Design for Antioxidant Diphenylamine Derivatives Using Quantitative Structure-Activity Relationships and Quantum Mechanics Calculations.

Diphenylamine (DPA) derivatives, used as antioxidants in rubber-based products, inhibit autoxidation by donating hydrogen atoms to peroxyl radicals. Octanol-water partition coefficient (LogK), an antioxidant index, helps predict their distribution in hydrophobic polymer matrices. Therefore, this study aimed to investigate the relationship between the structure of DPA derivatives and their antioxidant activities, using machine learning with quantitative structure-activity relationships (QSAR) and quantum mechanics (QM).

Artonin F Induces the Ubiquitin-Proteasomal Degradation of c-Met and Decreases Akt-mTOR Signaling.

Targeted therapies that selectively inhibit certain molecules in cancer cells have been considered promising for cancer treatment. In lung cancer, evidence has suggested that mesenchymal-epithelial transition factor (c-Met) oncoprotein drives cancer progression through its signaling transduction pathway. In this paper, we report the downregulation of c-Met by artonin F, a flavonoid isolated from .