Publications by authors named "Ismail D Kilic"

Coronary dissection is a potential occurrence after lesion preparation for percutaneous coronary intervention (PCI). Unlike stents, drug-coated balloons (DCBs) do not allow to cover dissections, thus demanding an assessment of their safety in this setting. This study aimed to evaluate the incidence, predictors, and clinical outcomes of dissections occurring with DCB-based PCI for de novo coronary artery disease.

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Introduction: Pulmonary hypertension (PH) is a serious condition associated with high morbidity and mortality, with obesity identified as a significant risk factor. Pulmonary arterial stiffness (PAS) is an early marker of PH, often preceding clinical symptoms. While laparoscopic sleeve gastrectomy (LSG) has been shown to improve various cardiac parameters in obese patients, its impact on PAS and right ventricular (RV) function in the absence of PH remains unclear.

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Article Synopsis
  • - The study focuses on improving the diagnosis of myocarditis using cardiac magnetic resonance imaging (CMRI) and investigates how common right ventricular (RV) involvement is in patients with acute myocarditis.
  • - Researchers analyzed CMRI data from 27 patients with acute myocarditis and compared it with a control group of 27 healthy individuals, finding significant differences in LV ejection fraction.
  • - Results indicated that while conventional RV assessment didn't show significant differences, CMRI-derived RV strain values were lower in the myocarditis group, suggesting potential subclinical RV dysfunction despite normal RV ejection fraction.
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Background: In this study, we aimed to examine the telomerase activity and hTERT gene expression in patients with acute coronary syndrome (ACS) and those with stable coronary artery disease (SCAD) and compare the results to controls. Additionally, we compared overall mortality rates relative to the telomerase activity.

Methods: A total of 211 patients (78 ACS and 71 SCAD patients) were included in the study.

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Background And Objective: Arterial stiffness, which is a measure of the elasticity of the arteries, is also a risk factor for the development of cardiovascular diseases and its measurement is important for evaluating the atherosclerosis process. The purpose of this cross-sectional study to investigate whether severe periodontitis in short-term type 2 diabetes may be associated with increased cardio-ankle vascular index (CAVI) values specified for subclinical atherosclerosis risk.

Methods: A total of 136 subjects, including 69 subjects with short-term type 2 diabetes (35 with severe periodontitis and 34 with periodontally healthy) and 67 systemically healthy subjects (32 with severe periodontitis and 35 with periodontally healthy) were enrolled to this study.

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Article Synopsis
  • - A 58-year-old man with a history of intermittent chest pain and palpitations presented to a cardiology clinic; he previously had a cardiac mass found via echocardiography 3 years ago but missed follow-up care.
  • - His medical history showed no other significant issues, but he has a family history of sudden cardiac death due to his father's heart attack at age 57.
  • - Physical and lab examinations were mostly normal, but ECG indicated sinus rhythm with ST depression, and further imaging tests (cardiac CT and MRI) were scheduled to assess the irregular left ventricle mass.
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Purpose: To investigate the effects of combination treatment with levothyroxine (LT4) and l- triiodothyronine (LT3) on left atrial volume (LAV), diastolic functions, and atrial electro-mechanical delays in LT4-treated women with low triiodothyronine (T3) levels.

Methods: This prospective study consisted of 47 female patients between 18 and 65 years old treated at an Endocrinology and Metabolism outpatient clinic between February and April 2022 due to primary hypothyroidism. The study included patients with persistently low T3 levels in at least three measurements, despite LT4 treatment (1.

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Introduction And Objective: With recent advances in genome sequencing technology, a large body of evidence has accumulated over the last few years linking alterations in microbiota with cardiovascular disease. In this study, we aimed to compare gut microbial composition using 16S ribosomal DNA (rDNA) sequencing techniques in patients with coronary artery disease (CAD) and stable heart failure (HF) with reduced ejection fraction and patients with CAD but with normal ejection fraction. We also studied the relationship between systemic inflammatory markers and microbial richness and diversity.

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Article Synopsis
  • - A 58-year-old man experienced chest pain and palpitations over 5 days, with a history of a cardiac mass found 3 years prior, but he lost follow-up care.
  • - His medical history was mostly unremarkable, but he had a family history of sudden cardiac death; he also exhibited high blood pressure during his physical exam.
  • - Diagnostic tests, including an ECG and echocardiography, indicated irregularities in the left ventricle, prompting further imaging with cardiac CT and MRI to evaluate the mass.
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The most common cause in the etiology of sudden cardiac death (SCD) is ischemic heart disease due to atherosclerosis. Postmortem diagnosis can be made by histopathological examinations, but routine histopathological examinations are limited, especially in the early period of postmortem ischemia. For this reason, many methods are being investigated for the postmortem diagnosis of ischemia, and postmortem biochemical studies are promising.

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Background And Aim: Pulmonary pulse transit time (pPTT) is a new marker of pulmonary hypertension (PH), which shows the time needed for the pulse wave to propagate from the right ventricular outflow tract to the left atrium (LA), but the relationship between pPTT and diastolic-LA function is almost unknown. In this study, we investigated the relationship between pPTT and LA-diastolic functions without PH.

Materials And Methods: One hundred and fifty-six patients were included in this prospectively designed study.

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Untreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long-standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right-sided heart failure. Early intervention results in favorable long-term outcomes making appropriate timing of intervention very critical. We present a 53-year-old male with severe symptomatic MR and right sided-heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list.

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Background: Approximately 5.8 million people experience peripheral arterial disease (PAD) in the United States today. Superficial femoral artery (SFA) disease is the most common cause of symptomatic PAD.

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Article Synopsis
  • The COVID-19 pandemic has highlighted the importance of telemedicine for housebound patients, especially those with cardiovascular conditions, prompting the need for further research and therapeutic management options.
  • Advances in telemedicine are enabling better monitoring and minor clinical decisions for patients with various cardiovascular diseases, fueled by the development of new monitoring technologies.
  • Despite making progress, challenges like data security, confidentiality, and reimbursement need to be addressed, and regulatory bodies must help establish a framework for effective telemedicine practices moving forward.
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Background: Heart failure with preserved ejection fraction (HFpEF) has been assessed extensively, but few studies analysed the predictive value of the NT-proBNP in patients with de novo and acute HFpEF. We sought to identify NT-proBNP at admission as a predictor for all-cause mortality and rehospitalisation at 12 months in patients with new-onset HFpEF. Methods: We analysed 91 patients (73 ± 11 years, 68% females) admitted for de novo and acute HFpEF, using the Cox proportional hazard risk model.

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Introduction: The relationship between mitral annular calcification (MAC) and the controlling nutritional status (CONUT) score has not been previously studied. In this study, we investigated the relationship between MAC and CONUT score to evaluate the nutritional status of patients with MAC.

Methods: A total of 275 patients, including 150 patients with MAC and 125 patients without MAC, who presented to a cardiology outpatient clinic were enrolled in the study.

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Purpose: To evaluate the prevalence and significance of incidental non-cardiac findings (NCFs) on cardiac magnetic resonance imaging (MRI). We also aimed to assess the unreported rate and clinical significance of NCFs in official radiological reports.

Material And Methods: Consecutive cardiac MRI examinations of 400 patients were retrospectively analysed and MR images reviewed by 2 observers blinded to official radiology reports.

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Pulmonary embolism is a common cardiovascular emergency. In case of delayed diagnosis and treatment morbidity and mortality is high. In this report, we presented a case of pulmonary embolism without apparent risk factors, which was initially misdiagnosed as peri/myocarditis.

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Article Synopsis
  • The study aimed to investigate the effects of the Orbital Atherectomy System (OAS) on vascular health in patients with peripheral arterial disease (PAD) and calcified lesions, assessing both immediate and long-term outcomes.
  • This involved evaluating 7 patients before and six months after treatment using a combination of diagnostic angiograms and intravascular optical coherence tomography (IV-OCT).
  • Results showed a 6% average increase in luminal volume after treatment, with most plaque removed being fibrous tissue, and a new algorithm for IV-OCT image classification was validated against expert analysis with 82% agreement.
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Nondiabetic patients have been studied to determine whether modest elevations in plasma mannose levels may be associated with a greater incidence of coronary artery disease (CAD). The plasma mannose, lipids (triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein) and lactate dehydrogenase levels were successfully evaluated with respect to subsequent CAD using records of 120 nondiabetic patients and 120 healthy volunteers. CAD was identified from myocardial infarction and new diagnoses of angina.

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  • - The study aimed to assess renal function in kidney transplant patients who underwent transcatheter mitral valve repair (TMVRep) to treat severe symptomatic mitral regurgitation (MR) one month post-treatment.
  • - A total of 22 patients with a history of end-stage renal disease were evaluated, showing significant reductions in serum creatinine levels after TMVRep, indicating improved renal function.
  • - The findings suggest that TMVRep may be a viable alternative to surgery for patients with renal transplants and severe MR, although further research is necessary to validate these results.
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