The permeability of human red blood cell membranes to hydrogen peroxide is independent of aquaporins.

Hydrogen peroxide (HO) not only is an oxidant but also is an important signaling molecule in vascular biology, mediating several physiological functions. Red blood cells (RBCs) have been proposed to be the primary sink of HO in the vasculature because they are the main cellular component of blood with a robust antioxidant defense and a high membrane permeability. However, the exact permeability of human RBC to HO is neither known nor is it known if the mechanism of permeation involves the lipid fraction or protein channels.

Diagnosis and treatment of congenital hemophilia with inhibitors a Latin American perspective.

The Committee of Latin America on the Therapeutics of Inhibitor Groups (CLOTTING) is composed of a number of hemophilia specialists from Latin America. The group aims to encourage the adoption of a good standard of care for Latin American patients with hemophilia. The occurrence of inhibitors in patients with hemophilia poses clinical challenges, and it is estimated that between 1000 and 3000 patients in Latin America are affected by hemophilia with inhibitors.