Design and Analyses of a Transdermal Drug Delivery Device (TD) †.

In this paper, we introduce a novel type of transdermal drug delivery device (TD) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD has shown to be capable of delivering a volumetric flow of 2.