Publications by authors named "Ismael Kamara"

The present study aimed to evaluate for the first time, the early molecular response (EMR) to imatinib at 3 months for patients with chronic myeloid leukemia and to determine the predictive factors that influence poor outcome and response. 60 newly diagnosed CML patients were enrolled from May 2018 to June 2023. They received imatinib and prospectively underwent a molecular evaluation.

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The degree of anaemia in sickle cell disease (SCD) is a well-known contributor to morbidity and mortality. We aimed to explore the factors affecting haemoglobin (Hb) level in African SCD patients, considering haemolysis biomarkers (LDH and bilirubin level, and reticulocyte count), leucocyte and platelet counts and socio-demographic characteristics (gender, age group, country of residence and BMI). The research was part of the CADRE multinational cohort and involved 3699 SCD patients living in Mali, Senegal, Ivory Coast, Democratic Republic of Congo, Gabon and Cameroon: 2936 SS/Sβ0, 587 SC and 176 Sβ + patients with median Hb level of 8, 11.

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Background: The diagnostic of cancer is generally associated with a psychological shock. Body's defense mechanisms and drugs cannot resolve emotional distress and symptoms of cancer. A need for psychosocial management of the African patient is necessary.

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Introduction: The diagnosis of chronic myeloid leukemia is based on the presence of translocation t(9,22). Additional cytogenetic abnormalities may exist at diagnosis and have prognostic value. The authors evaluated the relationship between these additional chromosomal abnormalities, clinical presentation, and therapeutic response.

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Context: The maxillo-facial attack was the first described in the Burkitt lymphoma in 1958 by Denis Pearsons Burkitt. Abdominopelvic disorders, particularly ovarian localization are observed more and more by the developments of imagery technics. Our study aimed to describe the epidemiologic, clinical, therapeutic and evolutive aspects of ovarian localization in the endemic Burkitt lymphoma.

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Several studies conducted in America or Europe have described major cardiac remodeling and diastolic dysfunction in patients with sickle cell disease (SCD). We aimed at assessing cardiac involvement in SCD in sub-Saharan Africa where SCD is the most prevalent. In Cameroon, Mali and Senegal, SCD patients and healthy controls of the CADRE study underwent transthoracic echocardiography if aged ≥10 years.

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Article Synopsis
  • - Growth failure (GF) in children with sickle cell disease (SCD) is prevalent in sub-Saharan Africa, affecting over 50% of specific SCD phenotypes, compared to controls.
  • - The study found that factors like lower parental education, male gender, and specific SCD types (HbSS and HbSβ) are positively linked to GF, while no connection to clinical complications was observed.
  • - In this context, GF is particularly common during adolescence and shows associations with haemolysis and microalbuminuria, indicating a need for targeted interventions.
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Article Synopsis
  • The study examines the relationship between steady-state hemolysis and vascular complications in sickle cell disease (SCD) patients from West and Central Africa, highlighting the need for context-specific research beyond North American data.
  • Researchers analyzed 2,407 SCD patients using a composite index for hemolytic intensity to assess complications like tricuspid regurgitant jet velocity (TRV), microalbuminuria, and leg ulcers.
  • Findings suggest that severe anemia is linked to certain vascular issues, but increased hemolysis does not independently explain these complications, indicating that other factors, such as nutrition and infections, may contribute to SCD-related vasculopathy.
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Background: Although a blood genetic disease, sickle cell disease (SCD) leads to a chronic vasculopathy with multiple organ involvement. We assessed arterial stiffness in SCD patients and looked for associations between arterial stiffness and SCD-related vascular complications.

Methods: The CADRE (Coeur Artères et Drepanocytose, ie, Heart Arteries and Sickle Cell Disease) study prospectively recruited pediatric and adult SCD patients and healthy controls in Cameroon, Ivory Coast, Gabon, Mali, and Senegal.

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Background: Chronic kidney disease is one of the leading causes of mortality in patients with sickle cell disease. However, it has been almost exclusively studied in patients with the SS phenotype and in high-income countries, despite more than 80% of patients living in Africa. We looked for the determinants of glomerulopathy in a multinational cohort of patients with sickle cell disease of different phenotypes in sub-Saharan Africa.

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We retrospectively studied 30 cases of multiple myeloma in patients under the age of 65, diagnosed from 1991 to 2005 in the clinical hematology department of the University Hospital of Yopougon that is a hospital incidence of 2.9 cases/year. The age of patients ranged from 34 to 64 years, with a mean age of 49 years and a sex ratio of 1.

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