Publications by authors named "Ismael Henarejos-Castillo"
Article Synopsis
- Ovarian failure (OF) affects around 1% of women under 40, often with unknown causes, which complicates personalized treatment approaches and highlights the need for genetic research.
- A study of 150 women’s genetic data identified 18 genes with significantly higher rates of genetic variations (SNVs) in those with OF compared to controls, suggesting new biological insights into the condition.
- Experimental validation in fruit flies showed that six of these genes were linked to reduced fertility, and the analysis also identified disruptions in key biological pathways important for ovarian function.
Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10-25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study sought to identify a blood-based gene variant profile using accumulation of rare variants to promote precision medicine in fertility preservation programs.
View Article and Find Full Text PDFObjective: To determine the susceptibility of the endometrium to infection by-and thereby potential damage from-SARS-CoV-2.
Design: Analysis of SARS-Cov-2 infection-related gene expression from endometrial transcriptomic data sets.
Setting: Infertility research department affiliated with a public hospital.