Publications by authors named "Isllan D'Erik Goncalves da Silva"
Genotoxic activity of L-asparaginase produced by Streptomyces ansochromogenes UFPEDA 3420.
Glêzia Renata da Silva Lacerda Jeanne Cristina Lapenda Lins Cantalice Gláucia Manoella de Souza Lima Luiz Eduardo Félix de Albuquerque Isllan D'Erik Gonçalves da Silva
World J Microbiol Biotechnol
February 2019
L-asparaginase is an enzyme capable of hydrolyzing the substrate asparagine in aspartic acid and ammonia. Due to this mechanism of action observed, L-asparaginase is widely used in the treatment of Acute Lymphoblastic Leukemia, since these cells use asparagine for their survival. Because it is frequently used as an antineoplastic, it is necessary to evaluate its genotoxic effects.
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