Publications by authors named "Islam S A Hassan"
Purpose: To compare clinical outcomes in a cohort of patients with advanced non-small-cell lung cancer (NSCLC) with targetable genomic alterations detected using plasma-based circulating tumor DNA (ctDNA) or tumor-based next-generation sequencing (NGS) assays treated with US Food and Drug Administration-approved therapies at a large academic research cancer center.
Methods: A retrospective review from our MD Anderson GEMINI database identified 2,224 blood samples sent for ctDNA NGS testing from 1971 consecutive patients with a diagnosis of advanced NSCLC. Clinical, treatment, and outcome information were collected, reviewed, and analyzed.
Article Synopsis
- Dexamethasone is commonly used to manage edema in glioblastoma (GBM) patients and affects gene expression in GBM stem cells, but its effects on invasion, proliferation, and angiogenesis in GBM are not fully understood.
- The study compared gene expression profiles of mesenchymal GBM samples to proneural ones and tested dexamethasone on different GBM stem cell lines to assess its impact on key cancer behaviors like invasion, proliferation, and angiogenesis.
- Results indicated that dexamethasone increased invasion and proliferation in some stem cell lines and was linked to worse outcomes in patients with mesenchymal GBM due to the upregulation of specific cancer-related pathways.