Midodrine improves clinical and economic outcomes in patients with septic shock: a randomized controlled clinical trial.

Background: Prolonged use of intravenous (IV) vasopressors in patients with septic shock can lead to deleterious effects.

Aims: This study assessed the impact of midodrine administration on weaning off IV vasopressors and its economic value.

Methods: It is a prospective randomized controlled study of 60 resuscitated patients with septic shock who demonstrated clinical stability on low-dose IV vasopressors for at least 24 h.