Elevated plasma levels of endostatin are associated with chronic kidney disease.

Background/aims: Angiogenesis may play an important role in the renal repair process after injury. We investigated the association between plasma endostatin, an endothelial-specific antiangiogenic factor, and chronic kidney disease (CKD).

Methods: We compared plasma endostatin levels in 201 CKD patients and 201 controls.

Increased urinary excretion of angiotensinogen is associated with risk of chronic kidney disease.

Background: The effect of intrarenal renin-angiotensin system (RAS) activity on risk of chronic kidney disease (CKD) has not been well studied in human subjects.

Methods: We investigated the association between urinary angiotensinogen, a reliable biomarker of intrarenal RAS activity, and risk of CKD in 201 patients and 201 controls. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.