Publications by authors named "Isio C Souza"
Acellular Biomaterials Associated with Autologous Bone Marrow-Derived Mononuclear Stem Cells Improve Wound Healing through Paracrine Effects.
Biomedicines
March 2023
Article Synopsis
- * In an experiment with forty male Wistar rats, four groups were studied: a control group, a group treated with BMSCs, a group covered by AM, and a group treated with both BMSCs and AM, to evaluate their effects on healing after a full-thickness skin lesion.
- * Results indicated that the combination of AM and BMSCs led to better healing outcomes, with lower levels of harmful cytokines and higher collagen production, suggesting these treatments promote
A perfect graft for wound care must be readily available without affecting the immune response, covering and protecting the wound bed. Considering previous studies have already established the use of hyaluronic acid (HA) for the treatment of wounds but the data presented on the amniotic membrane (AM) and its promising effects on healing still requires further investigation, this study aimed to evaluate the effects of the application of a decellularized amniotic membrane solubilized with hyaluronic acid on the healing process of cutaneous wounds on the 7th and 14th day, to evaluate the evolution of the wound and the inflammatory phases in these two times. Cutaneous lesions were excised from the dorsal region and 96 Wistar rats were divided into four groups: I-Excisional wound (EW); II-EW + AM; III-EW + HA; IV-EW + AM + HA.
View Article and Find Full Text PDFStem cells (SC) and amniotic membrane (AM) are recognized for their beneficial impacts on the healing of cutaneous wounds. Thus, this study evaluated the capacity of tissue repair in a skin lesion rat model. Forty Wistar rats were randomized into four groups: group I - control, with full-thickness lesions on the back, without SC or AM; group II-injected SC; group III - covered by AM; group IV-injected SC and covered by AM.
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