Publications by authors named "Isinsu Bastepe"
Article Synopsis
- The incomplete understanding of epididymal mucosal immunity complicates the diagnosis of many male infertility cases, often leaving them labeled as idiopathic.
- Disruptions like vasectomy or infections can trigger immune responses against sperm, leading to autoimmune reactions and chronic subfertility issues.
- The research highlights the role of regulatory T cells and the formation of tertiary lymphoid structures in the epididymis, indicating potential avenues for targeted infertility treatments and male contraceptive developments.
Intact fibroblast growth factor 23 (iFGF23) is a phosphaturic hormone that is cleaved by furin into N-terminal and C-terminal fragments. Several studies have implicated vitamin D in regulating furin in infections. Thus, we investigated the effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D] and the vitamin D receptor (VDR) on furin-mediated iFGF23 cleavage.
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