Publications by authors named "Isin Pak"

Objective: The purpose of this study was to evaluate the effects of beta-D-glucan on the experimental diabetic rat colon anastomosis model.

Background: Beta-D-glucan is a commonly used macrophage activator and promotes wound healing by increasing macrophage infiltration into the wound. The decrease in the function of macrophages and impaired wound healing can be observed in diabetes mellitus (DM).

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Introduction: Cylindromas are usually benign tumors as small, solitary, slow-growing nodules of the scalp, face and trunk. Multiple cylindromas may form a "turban tumors" in the autosomal dominant Brooke-Spiegler syndrome. Malignant dermal cylindromas are very rare.

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A case of a dermoid cyst with intracranial extension in a 48-year-old female is reported. Intracranial extension of a dermoid cyst is very rare. During its slow growth, it extends to the cranium from different regions by invading neighboring bones.

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Osteoid osteoma is a benign bone tumor, which rarely occurs in the skull, and often causes local pain that is worse at night, characteristically relieved by aspirin. Giant osteoid osteoma in the occipital bone is uncommon. We present a case of a 42-year-old female with an osteoid osteoma of the occipital bone that was totally resected.

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Cystic mature teratomas of the spinal cord are rare lesions. Teratomas account for up to 0.1% of all spinal cord tumors.

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Purpose: Multidrug resistance is resistance to structurally unrelated anticancer agents. Large-scale expression analysis by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to MDR. This study demonstrates alterations in expression levels of several genes related to epithelial-mesenchymal transition (EMT) in paclitaxel, docetaxel, and doxorubicin resistant MCF-7 cells.

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Background: FAS and its ligand, FASL, have important roles in the neoplasia-immunity relationship. In melanoma, the importance of FAS and FASL remains controversial, despite a group of studies. In this study, we aimed to demonstrate the distribution of FAS/FASL in melanotic lesions and to investigate the correlation between tumor infiltrating lymphocytes and macrophages.

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Aim: To assess sample volume (by its length and diameter) and sample quality (judging by its integrity) in CT-guided vertebral biopsy due to lesion location and needle trajectory method as individual study variables each.

Material And Methods: Of 48 patients, 25 were men and 23 were women; ranging from 33 to 85 years of age, with a median age of 65.5 years.

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Angiofibromas (AFs) originate predominantly in the nasopharynx and posterior nasal cavity. The incidence of these lesions is less than 0.5% among all neoplasms of head and neck.

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Aim: The purpose of this study was to investigate the possible role of human papillomavirus (HPV) in Turkish patients with epithelial ovarian cancer by using the highly sensitive technique of polymerase chain reaction (PCR) to identify all the subtypes of this unique oncogenic virus.

Methods: All patients were subjected to initial surgery, and subsequently recruited for postoperative chemotherapy depending on the extent of the disease and their condition. HPV PCR screening was done from paraffin embedded samples.

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Objective: To report the clinical and pathological features and surgical treatment outcomes of patients with granulomatous mastitis.

Design: Case series.

Place And Duration Of Study: Ankara Oncology Training and Research Hospital, between 1999-2003.

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Secretory breast carcinoma is a rare entity. It was first reported in pediatric patients in 1966, and was named juvenile breast carcinoma. Incidences of pediatric and adult patients are similar.

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Background: Placental site trophoblastic tumor (PSTT) is an uncommon variant of gestational trophoblastic diseases. In most cases, disease is confined to the uterus and treated with a simple hysterectomy. However, 30% of these patients will present with metastatic disease.

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