Assessing the clinical utility of pre-operative neutrophil-lymphocyte ratio as a predictor of clinicopathological parameters in patients being treated for primary breast cancer.

Background: There is a paucity of data supporting the role of neutrophil-lymphocyte ratios (NLR) to determine clinicopathological parameters in patients being treated for primary breast cancer.

Aims: To evaluate the association between pre-operative NLR and clinicopathological parameters in patients diagnosed with breast cancer.

Methods: A retrospective cohort study was performed.

A Systematic Review and Meta-Analysis of an Angiotensin Receptor-Neprilysin Inhibitor in Patients Using a Durable Left Ventricular Assist Device.

Sacubitril/valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI) drug used to treat patients with heart failure and has shown improvement in outcomes. Different studies reported the use of an ARNI in patients using left ventricular assist devices (LVADs). However, there are limited data on the use of ARNIs in this population.

Effect of the COVID-19 Pandemic on the Management of Breast Cancer Patients.

The COVID-19 pandemic has significantly affected breast cancer patients by causing delays in diagnosis and treatment processes. This study aims to investigate the effects of the pandemic on the treatment process and short-term outcomes of breast cancer patients. This retrospective, cross-sectional, single-center study included 414 patients who underwent surgery for breast cancer at the Inonu University General Surgery Clinic between March 2018 and June 2021.

A Systematic Review and Meta-Analysis of the Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitor in Patients Using Left Ventricular Assist Devices.

Sodium-glucose cotransporter-2 inhibitors (SGLT2-i) have been shown to reduce risks of clinical events in patients with heart failure (HF). However, data on the use of SGLT2-i in patients with left ventricular assist devices (LVADs) are scarce. We thought to assess the efficacy and safety of SGLT2-i in patients with LVADs.

Analysis of successful and unsuccessful snatch and clean and jerk lifts in IWF World Championships (2011-2023).

In this research, male and female athletes who won gold, silverand bronze medals at the International Weightlifting Federation Senior World Championship (between 2011 and 2023); (a) analysis of successful and unsuccessful lifts in snatch and clean and jerk techniques, (b) analysis of successful and unsuccessful lifts in 3 lift attempts in both techniques and, (c) It is aimed to investigate the lifting attempts of athletes that determine their medal rankings in snatch, clean and jerk and total. In this retrospective study, data of 3144 (1603 and 1541 for male and female, respectively) individual results obtained from the lifting performances of 528 athletes (male n = 270; female n = 258) participating in the Senior World Championship (between 2011 and 2023) in snatch and clean and jerk were analyzed. In the study, the frequencies and rates of the individuals included in the study according to different variables are presented with descriptive statistics.

Valorization of the performance of novel and natural sodium alginate/pectin/Portulaca oleracea L. ternary composites in the adsorption of toxic methylene blue dye from the aquatic environment.

This research introduces the development of a novel, sustainable, cost-effective, and eco-friendly sodium alginate (SA)-pectin (P) ternary composite, enhanced with Portulaca oleracea L. (PO) additive, which has been thoroughly investigated for its efficacy in removing hazardous methylene blue (MB) dye from wastewater. The selectivity studies using various cationic and anionic dyes were conducted.

Impact of neonatal intensive care nurses' work environments on attitudes towards patient safety: A cross-sectional study in Türkiye.

Aim: This study aimed to determine the effect of neonatal intensive care nurses' work environment on their attitudes towards patient safety.

Design: The study had a descriptive, correlational and cross-sectional designs.

Methods: The study included 304 neonatal intensive care nurses in Türkiye.

Preparation and characterization of oat hulls-filled-sodium alginate biocomposite microbeads for the effective adsorption of toxic methylene blue dye.

In this work, the performance of oat hull-filled sodium alginate (SA-O) biocomposite microbeads in the adsorptive removal of methylene blue (MB) dye was examined. First, oat hulls were pulverized and biocomposite gels containing different weight ratios of oat hulls (10 %, 20 %, and 30 %, concerning the SA amount) were prepared by dispersing them in SA solution by ultrasonic homogenization method. Finally, gels were cross-linked by dropping into a 2 % CaCl solution.

The Effectiveness of Immersive Virtual Reality Simulation as an Innovative Learning Strategy for Acquisition of Clinical Skills in Nursing Education: Experimental Design.

A transformation of learning in nursing is necessary to prepare students for developing complex clinical environments. The essential aim of clinical nursing learning is to enhance the integration of theoretical knowledge in the clinical environment by using various innovative strategies, such as immersive virtual reality (VR) simulation to develop a learning process that allows students to gain knowledge and perform skills in a visually attractive way, which enhances the quality and safety of clinical learning through repeated exposure to educational content that supports students' cognitive and psychomotor skills. This study was aimed at determining the effectiveness of immersive VR simulation as a learning strategy on the acquisition of intramuscular injection skills in nursing education and the performance level of nursing students compared with a physical learning environment (low-fidelity simulation).

A Classification for Gastric Outlet Obstruction in Childhood: Extending Beyond Infantile Hypertrophic Pyloric Stenosis.

Background/aims:  Gastric outlet obstruction (GOO) is a rare condition in childhood, with the exception of infantile hypertrophic pyloric stenosis (IHPS). However, no classification exists from a pediatric gastroenterologist's perspective.

Materials And Methods:  The patients with a diagnosis of GOO between 2009 and 2020 were reviewed retrospectively.

The relationship between TNF-α, IL-1, IL-12, IL-17, IL-23, IL-36 expression and treatment response in psoriasis histopathologically and immunohistochemically.

Aim: There is no marker that can predict whether there is resistance to treatment in patients with psoriasis. In this study, we investigated the relationship between the staining rates of TNF-α, IL-1, IL-12, IL-17, IL-23, and IL-36 markers immunohistochemically from cutaneous biopsy and the treatment success.

Methods: The patients who were followed up in the dermatology clinic with the diagnosis of plaque-type psoriasis vulgaris and received biological treatment and previously had cutaneous biopsy were included in the study.

Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology.

Models of inflammation, oxidative stress, hyperoxia and hypoxia have demonstrated that magnesium sulfate (MgSO), a commonly used drug in obstetrics, has neuroprotective potential. In the present study, the effects of MgSO treatment on inflammation, oxidative stress and fetal brain histopathology were evaluated in an experimental rat model following sevoflurane (Sv) exposure during the mid-gestational period. Rats were randomly divided into groups: C (control; no injections or anesthesia), Sv (exposure to 2.

An Elbow Patch Reconstruction Technique for Narrowed Remnant Portal Veins during Right Lobe Living Donor Hepatectomy: A Rescue Surgery.

Treatment of established portal vein narrowing after living donor hepatectomy is challenging. We aimed to present a new approach termed the "elbow patch reconstruction technique" to correct the narrowed remnant portal vein just or late after right lobe living donor hepatectomy. Demographic and clinical data of 12 living liver donors with narrowed remnant portal veins and treated with the "elbow patch reconstruction technique" were prospectively collected and retrospectively evaluated.

Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats.

Background: The role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus of previous studies. Cinnamon and its main components have been reported to have protective effects in various tissues with antioxidant and anti-inflammatory effects.

Aims: In this study, the protective effect of cinnamon extract (CE) against possible Co-induced heart, kidney, and liver damage in rats was investigated biochemically.

Evaluating the difference in perception of the Akinosi technique among dentistry students: A comparison between theoretical and practical learning.

Introduction: Effective pain control is crucial in dental practice; thus, local anesthetic techniques have been extensively taught. The Halstead technique is the most commonly used inferior alveolar nerve block despite its relatively high failure rate. On the other hand, the Vazirani‒Akinosi technique (VAT) is less commonly taught.

Novel optical coherence tomography findings in a patient with methanol toxicity: a case report.

We report a case of acute methanol toxicity with unique optical coherence tomography findings. A 56-year-old man was referred to our ophthalmology clinic with a history of handmade vodka consumption and vision loss. On ophthalmologic examination, his vision was 20/100 in his right eye and 20/200 in his left eye.

Transplant and non-transplant HCC patients at a single institution.

Background And Aim: Patients with hepatocellular carcinoma (HCC) are managed in various hospital departments, which complicates the assessment of the overall picture. In our large liver transplant institute, we evaluate all HCC patients in a weekly multi-disciplinary liver tumor board, and their data are prospectively collected in an institutional HCC database to evaluate HCC causes, tumor features, treatments, and survival.

Materials And Methods: Baseline data for patients (n=1322) were prospectively recorded, including hepatitis status, routine clinical serum parameters, radiological assessment of maximum tumor diameter (MTD), tumor number, presence of macroscopic portal vein thrombosis (PVT), and serum alpha-fetoprotein (AFP) levels.

Microvascular Invasion in Hepatocellular Carcinoma: Some Puzzling Facets.

Background/aims: Hepatocellular carcinoma is the main type of primary liver cancer. Macroscopic vascular invasion is usually identified during imaging, whereas microvascular invasion is usually determined by histopathological evaluation. We aim to identify the association between microvascular invasion and other markers of tumor aggressiveness and to identify the role of microvascular invasion in the prognosis of patients who were treated by liver transplantation for hepatocellular carcinoma.

Primary splenic abscess in an adult female patient: a case report.

Background: Primary splenic abscess is rare and typically presents in patients who are immunocompromised. We present a case of a 47-year-old apparently immunocompetent female patient who was diagnosed with primary splenic abscess from a Salmonella Typhimurium infection following emergency laparotomy.

Case Presentation: A 47-year-old female patient presented with subjective fever and severe epigastric and left flank pain.

Investigation of Physicochemical Characteristics of Aspergillus niger Biomass and Examination of Its Ability to Separate Butyl Acetate Isomers.

Aspergillus niger is a species of fungus that is widely found in natural ecosystems and has an important role in various industrial fields and is readily available. To study the adhesion of microbial cells to solid substrates and to improve their properties, physicochemical characterization of microorganisms is extremely important. For this purpose, in this study, the surface properties of A.

Evaluating emergency department visits for spontaneous and traumatic pneumomediastinum: a retrospective analysis.

Background: Pneumomediastinum signifies the accumulation of air within the mediastinum. This condition can develop sponta-neously or as a secondary condition due to trauma or iatrogenic causes. Although rare, it is part of a wide differential diagnosis scale due to its most common presenting symptoms: chest pain and shortness of breath.

Alpha-fetoprotein and albumin inversely relate to each other and to tumor parameters in patients with hepatocellular carcinoma.

Background And Aim: Alpha-fetoprotein (AFP), an oncofetal protein and biomarker in hepatocellular carcinoma (HCC), has unclear roles and actions.To evaluate the relationships between AFP, liver function tests, and HCC aggressiveness.

Materials And Methods: A retrospective analysis of an HCC patient database was conducted to examine the relationships between baseline serum AFP values, liver function tests, and tumor characteristics.

The predictive effect of identity functions of nursing students on their global social responsibility tendencies: A cross-sectional study.

Background: Global social responsibility is a concept related to being responsible for all living creatures, nature, and the world that all these form as a whole. Identity functions indicate what psychological gains the individual has through a feeling of a successfully structured identity.

Objective: To explore the predictive effect of identity functions of nursing students on their global social responsibility tendencies.

Discordance among aggressiveness characteristics of hepatocellular carcinoma: Portal vein thrombosis and multifocality, related to tumor size, but not to serum alpha-fetoprotein level.

Background And Aims: Hepatocellular carcinoma (HCC) is characterized by several clinically important prognostic parameters, including portal vein thrombosis (PVT), tumor multifocality, and serum alpha-fetoprotein (AFP) levels, in addition to maximum tumor diameter (MTD). However, associations among these parameters have not been thoroughly examined. Thus, the study aimed to investigate the correlations among these HCC characteristics in a prospectively collected database.