Publications by authors named "Isik A"

This study aims to evaluate the prognostic significance of various laboratory parameters in predicting the length of hospital stay and mortality among pediatric patients undergoing lobectomy and pneumonectomy for infectious or noninfectious diseases. This study was conducted by retrospective data analysis of 59 pediatric patients who underwent lobectomy and pneumonectomy due to variable diseases at the department of chest surgery. Pediatric patients diagnosed with variable diseases and who underwent lobectomy or pneumonectomy, patients who were hospitalized during the study period and underwent surgical intervention, and patients who had at least one laboratory parameter recorded before surgery were included in the study.

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Background: Around five billion people globally lack access to safe, timely, and affordable surgical facilities and care in low-income and middle-income countries (LMICs). Global initiatives have been launched, including efforts led by organizations. Also, regional efforts have shed light on the unique challenges faced by different areas within LMICs.

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Objective: This study aimed to investigate the most appropriate treatment options for patients with non-epithelioid malignant pleural mesothelioma.

Methods: We retrospectively analyzed patients with non-epithelioid malignant pleural mesothelioma who received treatment at our center.

Results: Forty-two patients were included in this study.

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In this study, we propose identifying potential novel compounds targeting carbonic anhydrase I and II. Herein, we have designed and synthesized new benzimidazole-hydrazide-hydrazones derivatives (4a-4r) to investigate the effects of these synthesized compounds on CA isoenzymes. The compounds' H NMR, C NMR, and HRMS spectra were used to confirm their chemical structures.

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Post-intubation tracheal stenosis (PITS) is a serious complication of prolonged intubation, often requiring surgical intervention. This study aims to present the long-term outcomes of patients with PITS who underwent tracheal resection and reconstruction, as well as to discuss the efficacy of these surgical methods in comparison to stenting. This retrospective study included patients treated for PITS at our center between October 2005 and October 2022.

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  • * A study involving 109 patients with RLS and 220 without RLS revealed that those with RLS had higher rates of comorbid conditions like coronary artery disease and hypertension, and higher instances of sarcopenia.
  • * The results indicated a significant correlation between RLS and a higher likelihood of both probable sarcopenia and actual sarcopenia, as well as slower gait speed in older patients with RLS.
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Background: The COVID-19 pandemic has seriously affected older adults' social lives, physical activity, and cognitive functions. Additionally, the lockdowns have disrupted regular healthcare for patients with chronic illnesses or needing acute care. Furthermore, the pandemic has negatively affected different psychosocial influences in each country due to the various cultural characteristics, technology, health system, and financial opportunities.

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  • Older patients with idiopathic normal pressure hydrocephalus (iNPH) are at a higher risk for osteoporosis, which may worsen their chances of falls and fractures.
  • The study included 64 iNPH patients and 458 controls, finding that osteoporosis was significantly more prevalent in the iNPH group (51.6% vs. 32.1%).
  • Raising awareness and implementing screening and treatment for osteoporosis in older individuals with iNPH is essential to prevent further health issues.
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Aim: This study aims to evaluate the reliability and validity of the Turkish version of the Standard Assessment of Global Everyday Activities (SAGEA) scale in older adults.

Methods: The study employed a cross-sectional, methodological design. The SAGEA scale was administered twice, with a two-week interval for test-retest reliability.

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Complications are plausible events during surgical operations. Surgical complications profoundly impact surgeons, often called "second victims" of adverse events. These complications trigger a range of emotional and psychological responses, including guilt, anxiety, heightened empathy, and the looming threat of burnout.

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Sudden idiopathic hearing loss (SIHL) is defined as sensorineural hearing loss at 30 dB or more at 3 consecutive frequencies that begins within 72 hours, and the etiology of the disease is still unclear. Steroid treatment is used as systemic and local (intratympanic) in sudden hearing loss, and different results have been reported for both treatment modalities. This study aimed to compare the results of the treatment in patients who received systemic steroid (SS) therapy and in patients who received systemic and intratympanic steroid (ITS) therapy for SIHL.

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  • The study investigates how fatty acid metabolism genes affect milk production traits in Jersey cows, focusing on identifying effective genetic markers.
  • The researchers compiled data on milk traits from multiple lactations, genotyped key genes, and analyzed the relationship between genetics and milk output using statistical models.
  • Findings indicate significant impacts of specific genes on milk yield and fat production, along with novel interactions that highlight the GGAAGG haplotype as a potential marker for assessing milk fat content.
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Objective: The aim of this study was to assess the relationship between cognitive and physical frailty and malnutrition in older adults.

Methods: The study was cross-sectional and observational. A total of 992 patients who applied to the geriatric outpatient clinic between January 2018 and December 2022 were included in the study.

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Cardiovascular autonomic dysfunction is one of the supportive clinical features in dementia with Lewy bodies (DLB). This study aimed to investigate the frequency of postural and postprandial hypotension in people with DLB. The study group comprised 125 patients with DLB (76 females; mean age 78.

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Background: The Kahramanmaras earthquakes in Turkey on February 6, 2023, resulted in more than 100 000 injuries and 50 500 deaths. The main causes of morbidity and mortality in earthquake-affected patients include crush syndrome, trauma-related extremity injuries, and wound infections.

Objective: To investigate infective complications, causative microorganisms, treatments, and treatment responses in pediatric patients.

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Aim: This study was conducted to investigate the impacts of scenario-based aging simulation experience (SBASE) on students' empathy, attitudes toward and willingness to work with older adults.

Background: Innovative teaching strategies such as SBASE have the potential to provide students with the essential skills required for working with older adults.

Design: This study has a randomized controlled trial.

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  • Purpura fulminans (PF) is a serious condition that leads to blood clotting issues, causing serious skin and tissue damage.
  • A 4-year-old girl developed PF after a chickenpox infection, resulting in severe skin lesions and requiring amputation after multiple treatments over 26 weeks.
  • Vaccination against varicella-zoster virus (VZV) is crucial as it can prevent serious complications like PF, despite VZV usually causing mild illness.
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Emergency general surgeons often provide care to severely ill patients requiring surgical interventions and intensive support. One of the primary drivers of morbidity and mortality is perioperative bleeding. In general, when addressing life threatening haemorrhage, blood transfusion can become an essential part of overall resuscitation.

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Background: Prevention and early intervention of alcohol use disorder (AUD) is a public health priority, yet there are gaps in our understanding of how AUD emerges, which symptoms of AUD come first, and whether there are modifiable risk factors that forecast the development of the disorder. This study investigated potential early-warning-sign symptoms for the development of AUD.

Methods: Data were from the RADAR study, a prospective cohort study of contemporary emerging adults across Australia (n = 565, mean age = 18.

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Introduction: There is still a requirement for concise, practical scales that can be readily incorporated into everyday schedules and predict the likelihood of dementia onset in individuals without dementia. This study aimed to assess the reliability of the ANU-ADRI (Australian National University Alzheimer's Disease Risk Index)-Short Form in Turkish geriatric patients.

Methods: This methodological study involved 339 elderly patients attending the geriatric outpatient clinic for various reasons.

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  • Tamoxifen is a common treatment for a type of breast cancer, but some patients can become resistant to it, meaning the medicine doesn't work anymore.
  • A long non-coding RNA called LINC00152 stops cells from dying in a specific way when tamoxifen is used, which makes the cancer harder to treat.
  • Researchers discovered that blocking LINC00152 can help make tamoxifen work better by changing how certain proteins and chemicals behave in the cancer cells, leading to more effective treatment.
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  • The trauma mortality rate is higher in elderly patients due to age-related physiological changes and frailty, necessitating specialized management guidelines to improve outcomes and minimize unnecessary procedures.
  • Expert surgeons reviewed literature and developed evidence-based recommendations for geriatric trauma care, focusing on frailty assessment, early activation of trauma protocols, and multimodal pain management.
  • Key practices include administering antibiotics selectively for certain traumatic injuries, ensuring timely venous thromboembolism prevention, and involving palliative care teams to address end-of-life discussions with a holistic approach.
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Objective: Idiopathic normal pressure hydrocephalus (iNPH), a classical triad of gait abnormality, cognitive disturbance, and urinary incontinence, increases in prevalence with aging. Sarcopenia is also characterized by low muscle strength and mass, contributing to gait difficulty. Gait abnormality and lower physical activity also lead to the development of sarcopenia.

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