Publications by authors named "Isidoro Chinchon"
We report a striking abundance of rimmed vacuoles in two brothers with X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) confirmed by the absence of emerin at the muscular nuclear envelope and by genetic analysis showing a new 2-bp deletion in exon 6 of the STA gene at the Xq28 region. Immunohistochemical analysis of the vacuoles revealed expression of dystrophin but not of merosin in the sarcolemma of rimmed vacuoles and absence of amyloid and membrane attack complex (MAC) deposition either in vacuoles or muscle fibers. The presence of rimmed vacuoles can be a histopathological finding in X-EDMD, and the diagnosis should not be excluded in clinically well-defined EDMD patients because of this finding.
View Article and Find Full Text PDFPrimary lymphoma of the central nervous system and HTLV-I infection.
Haematologia (Budap)
November 2002
Article Synopsis
- The study focuses on two HIV-positive intravenous drug users with primary CNS T-cell lymphomas, which are rare in AIDS cases.
- Both cases tested positive for HTLV-I, with one confirmed through multiple methods while the second showed indeterminate results.
- The researchers suggest that HTLV-I infection may have contributed to the development of T-cell lymphomas in these patients, although they do not fully align with acute T-cell lymphoblastic leukemia (ATLL) cases.