Publications by authors named "Isidora Riobo"
Introduction: Engagement of the B-cell receptor with immobilized antigens triggers the formation of an immune synapse (IS), a complex cellular platform where B-cells recruit signaling molecules and reposition lysosomes to promote antigen uptake and processing. Calcium efflux from the endoplasmic reticulum (ER) released upon BCR stimulation is necessary to promote B-cell survival and differentiation. Whether the spatial organization of the ER within the B-cell synapse can tune IS function and B-cell activation remains unaddressed.
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- Genome instability is linked to histone imbalances affecting DNA integrity, and histones must be properly synthesized and modified before entering the nucleus to ensure chromatin assembly.
- The histone demethylase JMJD1B is essential for supplying adequate histones H3 and H4, and its reduced levels in melanoma cells lead to cytoplasmic accumulation of histones, causing chromatin assembly defects and increased DNA damage.
- Research shows that JMJD1B knockout in melanoma cells enhances their tumorigenic properties and correlates with higher genome instability, indicating that JMJD1B plays a crucial role in maintaining genome integrity and may act as a safeguard against oncogenic mutations.