Publications by authors named "Isidora Panez-Toro"
Classically, particle-induced periprosthetic osteolysis at the implant-bone interface has explained the aseptic loosening of joint replacement. This response is preceded by triggering both the innate and acquired immune response with subsequent activation of osteoclasts, the bone-resorbing cells. Although particle-induced periprosthetic osteolysis has been considered a foreign body chronic inflammation mediated by myelomonocytic-derived cells, current reports describe wide heterogeneous inflammatory cells infiltrating the periprosthetic tissues.
View Article and Find Full Text PDFAdvances in Osteosarcoma.
Isidora Panez-Toro Javier Muñoz-García Jorge W Vargas-Franco Axelle Renodon-Cornière Marie-Françoise Heymann
Curr Osteoporos Rep
August 2023
Article Synopsis
- This article reviews advancements in osteosarcoma treatment, focusing on new strategies like targeting signaling pathways, immune checkpoint inhibitors, and innovative drug delivery methods.
- Osteosarcoma, prevalent in children and young adults, poses a significant risk for metastasis, with survival rates notably lower when metastases are present at diagnosis.
- Despite improvements in immunotherapy and the ongoing exploration of the tumor microenvironment, effective treatments have remained stagnant over the past 40 years, highlighting the need for further research and clinical validation.