Counter-regulatory responses to -induced hypoglycaemia.

Background: (TO) has many biological activities including blood glucose regulation. Thus, it is being used in the treatment of diabetes mellitus. TO has been shown to cause insulin-mediated hypoglycaemia, which leads to post-hypoglycaemic hyperglycaemia.

Melatonin prevents and ameliorates lead-induced gonadotoxicity through antioxidative and hormonal mechanisms.

We investigated the effects of melatonin on sperm parameters and some biochemical markers in lead-exposed male Wistar rats. Lead (50 mg/kg bw/day) and/or melatonin (4 mg/kg or 10 mg/kg bw/day) was administered for 4 weeks, while 2-week lead exposure was preceded by or followed by 2-week treatment with both doses of melatonin in other groups. Lead reduced glutathione, catalase, adjusted testes weight, semen parameters but did not change malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, and total antioxidant capacity.

Role of reactive oxygen species-total antioxidant capacity status in Telfairia occidentalis leaves-associated spermatoprotective effect: a pointer to fatty acids benefit.

Background The present study used reactive oxygen species (ROS)-total antioxidant capacity (TAC) score to understand the role of redox status on the effect of Telfairia occidentalis (TO) on testicular parameters. The fatty acids (FAs) components of methanol extract of TO (METO) and its fractions were also identified with gas chromatography-mass spectrometry. Methods A total of 66 male Wistar rats were randomly divided in a blinded fashion into six oral treatment groups as follows: group I (control, n=6) received 10% ethanol (vehicle for TO administration).

Melatonin attenuates Δ-tetrahydrocannabinol-induced reduction in rat sperm motility and kinematics in-vitro.

The use of Cannabis sativa (CS) has been widely demonstrated to have detrimental effect on male reproductive functions. Despite the well-known existence of endocannabinoid and melatonergic systems in semen, the physiological significance of their interaction is not understood. We recently showed that melatonin exacerbates the CS-induced gonadotoxicity in-vivo.

Telfairia occidentalis Hook.f. - associated haematopoietic effect is mediated by cytokines but independent of testosterone: A preliminary report.

Ethnopharmacological Relevance: Telfairia occidentalis Hook.f. (TO) is popular in Nigeria for the ethnopharmacological use of its leaves to improve haematological parameters in normal and anaemic subjects.

Pharmacological mechanisms involved in the analgesia induced by ethanol extract of leaves.

Background: (HE) leaves are being used traditionally to relieve pain, and scientific studies have demonstrated their analgesic potential. This study attempted to elucidate the pharmacological mechanism(s) involved in the analgesic action of ethanol extract of leaves (EEHE).

Materials And Methods: Forty-two male Wistar rats were separately randomized into seven groups (n=6 rats in each group) for tail immersion and formalin tests.

Effects of methanolic extract of Moringa oleifera leaves on semen and biochemical parameters in cryptorchid rats.

While anti-oxidant effects of Moringa oleifera in much oxidative stress related diseases have been well reported, cryptorchidism on the other hand has been shown to cause oxidative stress. However, study is scanty on the likely role of Moringa oleifera in reducing cryptorchidism-induced oxidative stress in rats has not been studied. The present study looked into the effects of methanolic extract of Moringa oleifera leaves (MEMO) on semen and biochemical parameters in cryptorchid rats.

Effects of salt-loading hypertension on nociception in rats.

Background: There is on going controversy on the effect of experimentally induced hypertension on nociception. The effect of salt-loading-induced hypertension on pain was studied in male rats.

Method: Twenty-four male Sprague-Dawley rats (160-280 g) were divided into two groups.

Vitamins e and C alleviate the germ cell loss and oxidative stress in cryptorchidism when administered separately but not when combined in rats.

The antioxidant effects of vitamins C and E on cryptorchidism-induced oxidative stress were investigated in male Sprague-Dawley rats. Forty rats (200-250 g) were randomly divided in a blinded fashion into five groups (n = 8). Group 1 was sham operated and treated with vehicle (corn-oil, 10 mL/kg).