Deciphering HMGB1: Across a spectrum of DNA and nucleosome dynamics.

HMGB1 is the most abundant nonhistone nuclear protein, which has been widely studied for its roles in the cytoplasm as an autophagy mediator and in the extracellular matrix as an inflammatory molecule. Studies concerning HMGB1's actual role and its binding within the nucleus are inadequate. Through this in vitro study, we aimed to discern the binding parameters of HMGB1 with various types of DNA, nucleosomes, and chromatin.

A Multiple Controlled Toffoli Driven Adaptive Quantum Neural Network Model for Dynamic Workload Prediction in Cloud Environments.

The key challenges in cloud computing encompass dynamic resource scaling, load balancing, and power consumption. Accurate workload prediction is identified as a crucial strategy to address these challenges. Despite numerous methods proposed to tackle this issue, existing approaches fall short of capturing the high-variance nature of volatile and dynamic cloud workloads.

Awareness about breast cancer in males in urban area of Delhi.

Background: Breast cancer in males is still an issue that is not known to majority of the population across the globe. People in general are not aware that breast cancer can occur in males too as increasing campaigns are done to raise awareness in females.

Objective: To assess the level of awareness of male breast cancer (MBC) in males of urban population residing in the Soami Nagar colony, Panchsheel, New Delhi.

Interaction of potyvirus helper component-proteinase (HcPro) with RuBisCO and nucleosome in viral infections of plants.

Bean common mosaic virus (BCMV) causes severe disease in Phaseolus vulgaris plants. One of its non structural protein, the helper-component proteinase (HcPro) involves in multiple roles in aphid transmission, RNA binding, suppression of gene silencing and protease activity. The multifunctional role of HcPro hint towards its regulation at multiple host cellular sites.

Elucidating the functional aspects of different domains of bean common mosaic virus coat protein.

The coat protein (CP) is the only structural protein present in the polyprotein of bean common mosaic virus. The well known characteristics of the CP are self-oligomerization and nucleic acid binding activity. The studies of the coat protein mutants revealed that the oligomeric property of CP solely depends on the amino-terminal residues and the nucleic acid binding domain present at the 194-202 residue position.