Ultralinear 140-GHz FMCW signal generation with optical parametric wideband frequency modulation enabling 1-mm range resolution.

We demonstrate ultralinear and ultrawideband frequency-modulated continuous-wave (FMCW) signal generation using an optical parametric wideband frequency modulation (OPWBFM) method. The OPWBFM method optically expands the bandwidths of FMCW signals beyond the electrical bandwidths of optical modulators via a cascaded four-wave mixing (FWM) process. Compared to the conventional direct modulation approach, the OPWBFM method simultaneously achieves high linearity and a short measurement time of the frequency sweep.

A case of pyogenic spondylitis caused by Paludibacteriumpurpuratum.

Paludibacterium purpuratum was first reported as a Gram stain-negative, curved, rod-shaped bacterium isolated from a wetland soil in 2016. We report the first case in the world, to our knowledge, of pyogenic spondylitis caused by P. purpuratum.

Photonic Armstrong method enabled by direct detection for wideband electrical PM generation.

Wideband signal generation using frequency/phase modulation (FM/PM) is the key fundamental function for various applications such as radar and analog communication systems. It is well known that analog FM/PM communication systems can dramatically improve signal quality by spectral expansion. In classical communication theories, the Armstrong indirect method is one of the most popular methods for bandwidth expansion of FM signals.

Multi-IF-over-fiber transmission using a commercial TOSA for analog fronthaul networks aiming beyond 5G.

An IF-over-fiber (IFoF)-based analog transport technology for mobile fronthaul applications has recently attracted significant attention. However, most previous studies have employed discrete optical components. For the analog transport technology to be a more cost-effective and power-efficient solution, it is necessary to utilize existing integrated optical transceivers.

Integrated dual-polarization coherent receiver without a polarization splitter-rotator.

We propose and demonstrate a simple integrated dual-polarization (DP) coherent receiver that does not require a polarization splitter-rotator (PSR). Based on a novel concept, a DP coherent signal is mixed with the local-oscillator (LO) waves inside a single interferometer and detected by five single-ended photodetectors. The signal-signal and LO-LO beat noises are eliminated through differential detection.

Association of T2/S-RNase With Self-Incompatibility of Japanese Citrus Accessions Examined by Transcriptomic, Phylogenetic, and Genetic Approaches.

Several citrus varieties show gametophytic self-incompatibility (GSI), which can contribute to seedless fruit production in several cultivars. This study investigated the genes regulating this trait through RNA-seq performed using styles collected from the flowers of Japanese citrus cultivars 'Hyuganatsu,' 'Tosabuntan,' 'Hassaku,' 'Banpeiyu,' and 'Sweet Spring'. We screened the transcripts of putative T2 RNases, i.

Complete retrieval of multi-level Stokes vector signal by an InP-based photonic integrated circuit.

An integrated Stokes vector receiver (SVR) that can retrieve state of polarization of light in the three-dimensional (3D) Stokes space has widespread applications, such as short-reach communication links, polarization-sensitive imaging, and sensing. While various approaches have been demonstrated to date, monolithic integration of polarization components on InP has been a challenging issue. In this paper, we develop a novel 4-port SVR circuit integrated on a compact InP chip to retrieve complete Stokes parameters of incoming light with various intensity and degree-of-polarization.

Polarization-diversity Stokes-analyzer-based coherent receiver.

Since the conventional coherent transceiver is costly to be deployed in short-reach networks due to its complicated receiver structure, it is desired to simplify the structure itself. In this paper, we propose a simple polarization-diversity coherent receiver structure by exploiting the concept of the Stokes analyzer. Compared to the conventional architecture, the number of the photodiodes (PDs) is reduced from eight to six without relying on complicated analog circuits.

Ectopic Fatty Acid-Binding Protein 4 Expression in the Vascular Endothelium is Involved in Neointima Formation After Vascular Injury.

Background: Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes, macrophages, and endothelial cells of capillaries but not arteries. FABP4 is secreted from adipocytes in association with lipolysis, and an elevated circulating FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. However, little is known about the link between FABP4 and endovascular injury.

Isolation and structure determination of a new lantibiotic cinnamycin B from Actinomadura atramentaria based on genome mining.

New lantibiotic cinnamycin B was isolated from the extract of Actinomadura atramentaria NBRC 14695(T), based on genome mining and chemical investigation. The partial structure of cinnamycin B was established by 2D NMR experiments, which indicated that cinnamycin B had same methyl lanthionine bridging pattern with cinnamycin. The reduction with NaBH4-NiCl2 afforded the reduced cinnamycin B, and MS/MS experiment indicated the presence of hydroxy asparatic acid in the molecule.

Local Production of Fatty Acid-Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis.

Objective: Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages, and elevated circulating FABP4 level is associated with obesity-mediated metabolic phenotype. We systematically investigated roles of FABP4 in the development of coronary artery atherosclerosis.

Approach And Results: First, by immunohistochemical analyses, we found that FABP4 was expressed in macrophages within coronary atherosclerotic plaques and epicardial/perivascular fat in autopsy cases and macrophages within thrombi covering ruptured coronary plaques in thrombectomy samples from patients with acute myocardial infarction.

Single-pollen genotyping to estimate mode of unreduced pollen formation in Citrus tamurana cv. Nishiuchi Konatsu.

2n pollen formed by FDR in citrus. The Japanese local citrus cultivar, Nishiuchi Konatsu (Citrus tamurana hort. ex Tanaka; NK hereafter), has the ability to produce unreduced 2n pollen grains, allowing generation of polyploid progenies via sexual polyploidization.

Reduction of circulating FABP4 level by treatment with omega-3 fatty acid ethyl esters.

Background: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) mainly expressed in adipocytes is secreted and acts as an adipokine. Increased circulating FABP4 level is associated with obesity, insulin resistance and atherosclerosis. However, little is known about the modulation of serum FABP4 level by drugs including anti-dyslipidemic agents.

Reduction of serum FABP4 level by sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes mellitus.

Fatty acid binding protein 4 (FABP4), also known as adipocyte FABP or aP2, is secreted from adipocytes in association with lipolysis as a novel adipokine, and elevated serum FABP4 level is associated with obesity, insulin resistance, and atherosclerosis. However, little is known about the modulation of serum FABP4 level by therapeutic drugs. Sitagliptin (50 mg/day), a dipeptidyl peptidase 4 (DPP-4) inhibitor that increases glucagon-like peptide 1 (GLP-1), was administered to patients with type 2 diabetes (n = 24) for 12 weeks.

Multi-dimensional permutation-modulation format for coherent optical communications.

We introduce the multi-dimensional permutation-modulation format in coherent optical communication systems and analyze its performance, focusing on the power efficiency and the spectral efficiency. In the case of four-dimensional (4D) modulation, the polarization-switched quadrature phase-shift keying (PS-QPSK) modulation format and the polarization quadrature-amplitude modulation (POL-QAM) format can be classified into the permutation modulation format. Other than these well-known modulation formats, we find novel modulation formats trading-off between the power efficiency and the spectral efficiency.

Eight-state trellis-coded optical modulation with signal constellations of four-dimensional M-ary quadrature-amplitude modulation.

We apply the eight-state trellis-coded modulation (TCM) using signal constellations of four-dimensional M-ary quadrature-amplitude modulation (4D-MQAM) to optical communication systems for the first time to our knowledge. In the TCM scheme, the free distance of the trellis diagram is equal to the minimum distance between constellation points in partitioned subsets, which enlarges the coding gain effectively. In fact, its asymptotic power efficiency is 3-dB larger than that of the set-partitioned 4D-MQAM (SP-4D-MQAM) format, while their spectral efficiencies are the same.

Angiotensin II receptor blockers decrease serum concentration of fatty acid-binding protein 4 in patients with hypertension.

Elevated circulating fatty acid-binding protein 4 (FABP4/A-FABP/aP2), an adipokine, is associated with obesity, insulin resistance, hypertension and cardiovascular events. However, how circulating FABP4 level is modified by pharmacological agents remains unclear. We here examined the effects of angiotensin II receptor blockers (ARBs) on serum FABP4 level.

Ectopic expression of fatty acid-binding protein 4 in the glomerulus is associated with proteinuria and renal dysfunction.

Background/aims: Fatty acid-binding proteins (FABPs) are a family of intracellular lipid chaperones. Among FABPs, FABP1 (liver FABP) is expressed in proximal tubular epithelial cells in the kidney, and urinary FABP1 has been reported to reflect damage of proximal tubular epithelial cells. However, roles of other FABP isoforms in renal pathologies have not been reported.

FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms.

Objective: Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes, and elevated plasma FABP4 level is associated with obesity-mediated metabolic phenotype. Postprandial regulation and secretory signaling of FABP4 has been investigated.

Methods: Time courses of FABP4 levels were examined during an oral glucose tolerance test (OGTT; n=53) or a high-fat test meal eating (n=35).

Urinary excretion of fatty acid-binding protein 4 is associated with albuminuria and renal dysfunction.

Background: Fatty acid-binding protein 4 (FABP4/A-FABP/aP2) is expressed in not only adipocytes and macrophages but also peritubular capillaries in the normal kidney. We recently demonstrated that ectopic expression of FABP4, but not FABP1 known as liver FABP (L-FABP), in the glomerulus is associated with progression of proteinuria and renal dysfunction. However, urinary excretion of FABP4 has not been investigated.

Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury.

Endoplasmic reticulum (ER) stress and inappropriate adaptation through the unfolded protein response (UPR) are predominant features of pathological processes. However, little is known about the link between ER stress and endovascular injury. We investigated the involvement of ER stress in neointima hyperplasia after vascular injury.

Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.

Background: Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function.

Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature.

Eosinophilic granulomatosis with polyangiitis (EGPA), which was previously called Churg-Strauss syndrome, is a necrotizing systemic vasculitis of unknown cause accompanied by prominent eosinophilia. Cardiovascular complications, including eosinophilic myocarditis, are a major cause of mortality in this disorder. Acute pericarditis with slight pericardial effusion is a typical manifestation in EGPA, though hemodynamically significant pericardial effusion has been reported in a few cases.

Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.

Background: Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney and converts angiotensin (Ang) II to Ang-(1-7), a renoprotective peptide. Urinary ACE2 has been shown to be elevated in patients with chronic kidney disease. However, the effects of antihypertensive agents on urinary ACE2 remain unclear.

Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension.

Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and vascular remodeling of the pulmonary artery (PA). Recently, endoplasmic reticulum (ER) stress and inappropriate adaptation through the unfolded protein response (UPR) have been disclosed in various types of diseases. Here we examined whether ER stress is involved in the pathogenesis of PAH.